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Lec2_ProtSort_revised

Lec2_ProtSort_revised - Mitochondria continued Coupling...

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D103 Cell Biology SS1 2009 Lecture 9+10 © Grün - all rights reserved. Coupling oxidative metabolism (proton gradient) with phosphorylation of ADP (ATP synthase) is a key step for ATP production. Uncoupling sometimes biologically useful. - The inner mitochondrial membrane in brown adipose tissue contains thermogenin (UCP-1, an uncoupling protein): forms alternative pathway for the flow of protons back to matrix. - This results in consumption of energy in thermogenesis (heat production) rather than ATP production. - useful when heat production required, for example in cold environments, newborns or hibernating animals. Synthetic uncouplers (e.g. 2,4-dinitrophenol ) also exist and can be very toxic. 1 Cell Biology lecture 1 © Gross - all rights reserved. Mitochondria, continued….
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D103 Cell Biology SS1 2009 Lecture 9+10 © Grün - all rights reserved. mitochondria actin DNA 2 Mitochondria are abundant and distributed throughout the cell
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