Lect8_CellCycle

Lect8_CellCycle - Review/question session #1 This Wednesday...

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Review/question session #1 This Wednesday ( tonight ), Nov 16 7-9 pm, BS3 1200 D103 Cell Biology 1
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Why? • Need addtl cells for development • Need cells to maintain/repair body (+ adaptation ). (make millions of cells/second; without cell division, die in a few days) Requirements for typical cell division: Increase cell size (except early embryogenesis). copy genome accurately . Segregate duplicated genome to each of daughter cell . Segregate organelles to each daughter cell . Incorrect replication/regulation causes problems!! Insufficient division growth retardation, degeneration. Excessive division birth defects, cancer . Incorrect segregation of chromosomes similar effects. Cell Replication: big picture 2 Bio 103-Fall 2011 © Steven Gross
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Stem cells reside in a specialized location in different organs, called the 'niche'. Stem cells divide infrequently . Signaling is used to recruit stem cells to enter the cell cycle . " Transit amplifying " cells expand the population of cells derived from a stem-cell that are available to undergo differentiation. Terminal differentiation leave cell cycle Same principles are used in other organs - e.g. gut, testis, blood. keratinocytes on surface of skin (corneum) spinosum (desmosome -linked cells) Basale (stem cells) 3 Rate of cell division varies widely example: skin Bio 103-Fall 2011 © Steven Gross Required reading: pp. 1417-1424
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The Stem-cell process of generating epidermis highlights a critical issue: control of the cell cycle D103 Cell Biology 4 How is internal signals/monitoring combined with external inputs?
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Of what use is terminal differentiation? a.To prevent there being too many cells of a given type b.Makes cancerous progression difficult c.Useful for cell specialization d.Allows control of spatial organization of cells e.All of the above 5 Bio 103-Fall 2011 © Steven Gross
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Lect8_CellCycle - Review/question session #1 This Wednesday...

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