Lecture14_cancer

Lecture14_cancer - Cancer - Basic facts, Biology, Causes...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Page 1 Cancer - Basic facts, Biology, Causes and Mechanisms metastatic liver cancer Recommended Reading: MBOC 5e, pages 1205 - 1266
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 2 Hallmarks and terminology of cancerous cells The normal constraints on cell growth and division are ignored or bypassed by cancer cells. Cancer cells invade and colonize territories normally occupied by other cells Neoplasm or Tumor : a mass of cells proliferating uncontrollably . Benign tumor : cells are clustered in a single mass, usually enclosed by a basement membrane or organ capsule . Malignant tumor : cells have acquired the capacity to move from the primary tumor mass and invade surrounding tissues . Individuals with benign tumors usually have a (much) better chance of survival . Metastatic cancer is difficult to treat due the large numbers of tumors that can form at secondary sites . Example: conversion of a benign glandular tumor (adenoma) into a malignant adenocarcinoma
Background image of page 2
Page 3 Cancers are classified based on their tissue of origin Epithelial cell derived = carcinoma Connective tissue or muscle = sarcoma Blood forming tissues derived = leukemia and lymphoma Nervous system derived = various ; e.g. glioblastoma, astrocytoma, neuroblastoma Glandular phenotype - adenocarcinoma Approximately 90 % of cancers are carcinoma: Why? Most of cell proliferation occurs in epithelia Epithelia are more frequently exposed to physical and chemical damage
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 4 Cancer is a common disease Figures for the year 2004, from American Cancer Society Cancer is not a single disease ! On average half of those who develop cancer will die from it. Cancer is responsible for approximately 20% of deaths in US each year . The survival index varies dramatically for different cancers (e.g. skin (high) and pancreatic (low)) Total new cases = 1,368,030 Total deaths = 563,700
Background image of page 4
Page 5 Environment has a major impact on cancer rate Popular past time of drinking warm Calvados (apple brandy)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 6 Environment has a major influence on rate of cancer in human population
Background image of page 6
Page 7 Cancers result from somatic mutation Mutagens that can accelerate rate of development of cancer Chemical - e.g. from environment (major impact) - e.g. lung cancer Radiation - i.e. x-rays, uv - e.g. skin cancer Biological - viruses; e.g. herpes viruses, papilloma viruses -e.g. cervical cancer
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 21

Lecture14_cancer - Cancer - Basic facts, Biology, Causes...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online