Review2 - Review Questions from students: 1: how is the...

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Review 1 F09 D103 Cell Biology - lecture 11 © Gross- all rights reserved. Questions from students: 1: how is the golgi is disassembled during prophase? 2: what are the various mechanisms through which the spindles are set up? 3: To turn on the cell, do we phosphorylate the inactive complex with its previous CDK? For example, p21 inhibit G1/S-CDK & S-CDK, so how can we remove p21 from the complex? (by G1-CDK?). Secondly, how do we remove the inactive p27-M- CDK (by S-CDK?).? 4: Lec 10 slide 7. I do not understand the first statement, "ER fragment at prophase." I taught the nuclear envelope breaks down in metaphase, so why are there ER fragments in prophase? 5: Lec 10, slide 14 and 18: can we use kinesin 14 and kinesin 5 interchangeably? The color and the heads of these motor confuses me. 6: You kept using the abbreviation EM. What does that mean? For example, in slide 16, "EM of nuclear lamina"
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Review 2 F09 D103 Cell Biology - lecture 11 © Gross- all rights reserved. Questions from students: 7: N-linked glycosylation: where does the oligosacharide attach? Mentioned N- linked (ASN) Is this the only sequence? 8: How would defects in ApoB receptor affect intracellular intracellular & extracellular cholesterol levels? 9: Properties of AA?
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3 F09 D103 Cell Biology - lecture 11 © Gross- all rights reserved. 1: how is the golgi is disassembled during prophase?
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The Golgi network is disassembled during prophase Golgi complex and the ER fragment at prophase . Transport of vesicles between Golgi membranes requires interaction between GM130 and p115 . During mitosis , M-Cdk , plus another protein (p9) phosphorylates GM130 , which prevents its interaction with p115 . This
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Review2 - Review Questions from students: 1: how is the...

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