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SL+D103+lecture+6 - D103 Cell Biology Dr Shin Lin Lecture 6...

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D103: Cell Biology Dr. Shin Lin
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D103 Fall 2011 Lecture 6 © Lin All rights reserved Lecture 6 The Cytoskeleton II Microtubules 2 Recommended Reading: MBOC, 5th edition, p.992-996; 1021- 22; 1034-1035; 1047-1048
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D103 Fall 2011 Lecture 6 © Lin All rights reserved 1. Characteristics of microtubules 2. Microtubule dynamics during the cell cycle 3. Roles of microtubules in organelle positioning 3
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D103 Fall 2011 Lecture 6 © Lin All rights reserved Microtubules are polymers of tubulin heterodimers heterodimer ( -tubulin and -tubulin) polar protofilament Microtubule assembled from13 protofilaments GTP ( -tubulin) is hydrolyzed during assembly GTP ( -subunit) is never hydrolyzed 4 Note: unlike an actin filament, microtubule is a hollow tubule
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GTP cap at “plus end” D103 Fall 2011 Lecture 6 © Lin All rights reserved 5 There is a delay between addition of subunits and GTP hydrolysis on -tubulin β
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D103 Fall 2011 Lecture 6 © Lin All rights reserved 6
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Growing and shrinking microtubules Dynamic Instability D103 Fall 2011 Lecture 6 © Lin All rights reserved 7
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Control by MT-binding proteins D103 Fall 2011 Lecture 6 © Lin All rights reserved 8
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D103 Fall 2011 Lecture 6 © Lin All rights reserved The centrosome is the major microtubule organizing center (MTOC) Where are microtubules nucleated? 9
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D103 Fall 2011 Lecture 6 © Lin All rights reserved Centrosomes • centrioles (not universal!! not present in fungi, not in plants) • pericentriolar matrix: a diverse set of at least 100 proteins -tubulin (a tubulin isoform) as part of the -TuRC proteins The composition of the centrosome Tubulin organization in centrioles
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SL+D103+lecture+6 - D103 Cell Biology Dr Shin Lin Lecture 6...

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