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SL D103 lecture 11 S - D103 Cell Biology Dr Shin Lin Lecture 11 Signaling II Steroid thyroid vitamin D retinoid hormone signaling Principles part

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D103: Cell Biology Dr. Shin Lin
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Lecture 11 Signaling II
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Steroid, thyroid, vitamin D, retinoid hormone signal ing Principles, part II Different combinations of signals can elicit different responses. Concept of protein “domains” - modules comprised of a series of conserved amino acids, which have specific functional properties and are shared between many different proteins. Signaling processes can mediate a rapid or delayed response. Steroid, thyroid, vitamin D, retinoid hormone signaling. Recommended Reading: MBOC 5e, pages 175 - 190, 879 - 904 D103 Fall 2011 - Lecture 11 - Signaling II 3
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Core components of a simple generic extracellular signaling pathway stimulus receptor transduction effector response(s) D103 Fall 2011 - Lecture 11 - Signaling II 4
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Cells (like humans) respond in discrete ways to different combinations of signals Note - almost all cells require constant stimulation to remain alive. We'll revisit this issue later during control of apoptosis. c-maj c-min humans too ! D103 Fall 2011 - Lecture 11 - Signaling II 5
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Comparison of the primary amino acid sequence of different proteins from plants, protists and animals reveals the existence of regions of conserved amino acids that usually constitute functional domains – e.g. “WW” domain ID # of different proteins WW PIN1 TCRG1 IQGAP1 DRE4 WBP4 FCA Prp40 URN1 Fbp11 D103 Fall 2011 - Lecture 11 - Signaling II 6
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Conserved modular domains are found in a wide range of proteins where each domain performs a similar function domain binds to modified peptide oligo-peptide, DNA, RNA homodimerization phospholipid D103 Fall 2011 - Lecture 11 - Signaling II 7
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Modular domains mediate interactions between intracellular signaling proteins and associated molecules Similar functional „modules‟ are found in a wide variety of different proteins involved in signaling D103 Fall 2011 - Lecture 11 - Signaling II 8
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occur rapidly or slowly slow due to requirement for de novo transcription and/or translation to synthesize new protein fast, with no requirement for de novo transcription and/or translation to synthesize new protein. Usually involves function of GTPases, kinases or phosphatases. D103 Fall 2011 - Lecture 11 - Signaling II
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This note was uploaded on 12/13/2011 for the course BIOSCI d103 taught by Professor Staff during the Fall '11 term at UC Irvine.

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SL D103 lecture 11 S - D103 Cell Biology Dr Shin Lin Lecture 11 Signaling II Steroid thyroid vitamin D retinoid hormone signaling Principles part

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