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Unformatted text preview: function. 3) Apoptosis is programmed cell death in which normal cells with irreparable DNA damage are programmed to die. Apoptosis is genetically controlled by specific proteins like Bcl-2 and BAX. The relative concentration of these two proteins is crucial in apoptosis. In normal cells, Bcl-2 and BAX are in equal proportions and bind to form inactive heterodimers. Excess of Bcl-2 results in formation of Bcl-2 homodimer which prevents apoptosis whereas excess of BAX forms BAX homodimers which promote apoptosis. In normal cells, p53 induces transcription of BAX and inhibits that of Bcl-2, leading to cell death. In cancer cells, defective p53 fails to induce the apoptotic pathway leading to continuous cell growth. Problem: Discussion question #6 from the text book. Answer at page A-43...
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This note was uploaded on 12/13/2011 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.
- Fall '08