300_sample_exam

300_sample_exam - Biochem 300 - Summer Sample Practice Exam...

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Biochem 300 - Summer Sample Practice Exam 1. Which of the following statements correctly describes telomerase? a) Telomerase carries its own DNA template. b) Inactivation of telomerase contributes to the extended life span of cancer cells. c) Telomerase extends the 3’-ends of the parent strands of linear chromosomes. d) Telomerase separates the circular daughter strands in E. coli DNA replication. e) Telomerase unwinds the DNA in the pre-priming stage of DNA replication 2. Which of the following is a ribozyme? a) Type I introns b) Type II introns c) RNA P d) Peptidyl transferase e) a and b f) a, b, and c g) all are ribozymes 3. 5’-3’ exonuclease activity is important in a) DNA pol III to remove RNA primer b) DNA pol III for proof reading c) DNA pol I for proof reading d) None of the above e) All of the above 4. A-DNA differs from B-DNA in that a) It has more base pairs per turn b) It has a tighter twist to it c) Its minor groove is more accessible d) None of the above e) All of the above 5. The Dna B protein a) Is a helicase that unwinds the DNA duplex b) Sits on the leading strand c) Uses the energy from supercoiling d) Binds to sites at oriC to coil the DNA in the initiation complex e) None of the above 6. Replication elongation on the lagging strand in E. coli a) Is the lagging strand of the opposite replication fork b) Has the template strand read discontinuously from 5’ to 3’ c) Does not require topoisomerase d) None of the above
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7. Which of the following enzymes is not required for E. coli DNA replication? a) gyrase b) DNA polymerase I c) helicase d) DNA ligase e) telomerase 8. Which of the arrow(s) best represent the position and direction of leading strand DNA synthesis? 9. The diagram below shows a series of okazaki fragments as well as possible locations for the beginning of the next okazaki fragment. Which arrow represents the location at which the next primer will be synthesized?
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10. The role of an enhancer in eukaryotic gene regulation is to: a) increase the replication of a specific gene. b) increase the transcription of a specific gene. c) increase the half-life of a specific polypeptide. d) increase the half-life of a specific mRNA. e) increase the translation of a specific mRNA. 11. In prokaryotic transcription, the role of sigma factor is: a) to catalyze the formation of phosphodiester bonds. b) to position RNA polymerase at an initiation site. c) to release the completed transcript from the template DNA. d) to separate DNA strands during elongation. e) to terminate transcription at specific secondary structures. 12. The E. coli arabinose operon encodes three enzymes that convert the sugar arabinose into xylulose 5-phosphate (an intermediate in the pentose phosphate pathway). Which of the following mechanisms would most likely be used to produce the three different enzymes from a single RNA transcript? a)
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300_sample_exam - Biochem 300 - Summer Sample Practice Exam...

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