PS1 - nerve cell, crosses the synaptic cleft and binds to a...

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Problem set 1: 1. Hydrophobic amino acids tend to group themselves in the cores of proteins a) What interaction is mediating this? Explain how it occurs. b) List four amino acids you would expect to find in the core of proteins. Include structures and abbreviations. c) What is the rational that the R groups of the amino acids you listed above are of different shapes? 2. Given the following reaction for which the pK a is 6.86 H 2 PO 4 - H + + HPO 4 2- a) What would the molar ratio of [H 2 PO 4 - ] to [HPO 4 2- ] be in order to have a pH of 7.2? b) Define the term buffer. Would this be a good buffer system at pH 7.2? Why or why not? 3. The amino acid glutamate is also used as a neurotransmitter. It is released from one
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Unformatted text preview: nerve cell, crosses the synaptic cleft and binds to a glutamate receptor on a second nerve cell, triggering a response. a) Draw the structure of glutamate b) In order for glutamate to interact with the receptor, it must form multiple interactions within the binding site. For each of the functional groups on glutamate, indicate which groups of amino acids (including a representative example) could be present in the receptor to bind specifically glutamate. Make sure to include two different types of interactions. c) Would you expect to see a large number of higher energy interactions? Textbook problems: Chapter 2: Q. 3, 5, 6, 7, 8, 9, 13. Pages 63-64...
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This note was uploaded on 12/13/2011 for the course BIOLOGY 300 taught by Professor Asdf during the Spring '08 term at The University of British Columbia.

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