tutorial7_ans - Bioc 300 Tutorial 7 Biochem 300 Tutorial 7...

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Bioc 300 – Tutorial 7 Biochem 300 – Tutorial 7 – July 30 th Topics : Cholesterol synthesis and regulation, lipid transport
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1. Understanding Cholesterol a) Draw the structure of cholesterol b) How would cholesterol be found/oriented in a cell membrane? And why might it be useful in cell membranes? c) Outline the major steps involved in producing cholesterol from acetyl-CoA’s. d) List the five major steroid hormones (derivatives of cholesterol) and provide one example and function for each.
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Cholesterol (a) Acts as a buffer for membrane fluidity by both interrupting lipid packing (when its cold) and holding them together (when its hot) (b) Like the other membrane lipids, cholesterol arranges itself in the same direction; its polar head is lined up with the polar headgroups of the phospholipid molecules
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Cholesterol Synthesis Steps (1) acetyl-CoA + acetyl-CoA acetoacetyl- CoA acetoacetyl-CoA + acetyl-CoA HMG- CoA
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Cholesterol Synthesis Steps (2) HMG-CoA Mevalonate Mevalonate IPPP
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Cholesterol Synthesis Steps (3) IPPP dimethyl allyl pyrophosphate (isomer) IPPP + dimethyl allyl pyrophosphate geranyl pyrophosphate IPPP + geranyl pyrophosphate farnesyl pyrophosphate
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Cholesterol Synthesis (4) 2 farnesyl pyrophosphates squalene Cyclization, and then a whole lot more reactions
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(d) 5 major steroid hormones: a) Progestagens - ex. Progesterone – used in the menstrual cycle (to prepare the ovum for implantation) b) Androgens - ex. testosterone – development of male sex characteristics c) Estrogens - ex. Estrogen – development of female sex characteristics d) Glucocorticoids - ex. Cortisol – anti-inflammatory, promotes
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This note was uploaded on 12/13/2011 for the course BIOLOGY 300 taught by Professor Asdf during the Spring '08 term at The University of British Columbia.

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tutorial7_ans - Bioc 300 Tutorial 7 Biochem 300 Tutorial 7...

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