tutorial9 - Tutorial 9 Biochem 300 Tutorial 9 Aug 9th 2009...

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Tutorial 9 Biochem 300 – Tutorial 9 – Aug 9 th 2009 Topics: Regulation/Integration of metabolism
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1. [PS8] Predict the major consequence of each of the following enzymatic deficiencies: - Glucose 6-phosphatase in liver - Carnitine acyltransferase I in skeletal muscle - Thiolase in brain - Kinase in liver that synthesizes fructose- 2,6-bisphosphate
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2. [PS8] Predict the major consequence of each of the following mutations affecting glycogen utilization: - Loss of GTPase activity of the G-protein alpha subunit - Loss of the gene that encodes inhibitor 1 of protein phosphatase 1 - Loss of phosphodiesterase activity
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3. Circle the best choices for each part of the paragraph. Glucagon [ inhibits / stimulates ] protein kinase A (PKA) signaling in liver cells leading to the activation of the FBPase-2 domain of the dual function enzyme PFK- 2/FBPase-2 which results in [ increased / decreased ] levels of F-2,6-BP. In contrast, insulin signaling in liver cells leads to the
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This note was uploaded on 12/13/2011 for the course BIOLOGY 300 taught by Professor Asdf during the Spring '08 term at The University of British Columbia.

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tutorial9 - Tutorial 9 Biochem 300 Tutorial 9 Aug 9th 2009...

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