Lecture 3 Outline

Lecture 3 Outline - BIOL 200(Section 921 Lecture 3 UNIT 3...

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BIOL 200 (Section 921) Lecture # 3 UNIT 3 June 17, 2009 UNIT 3: CHROMOSOMES, CHROMATIN; THE INTERPHASE NUCLEUS Reading for unit 3 on Interphase nucleus (Lecture 3): ECB 2 nd edition, Chap 5 pp. 177-191, Chap 15 pp. 502-506, Chap 17 p. 578, Chap 19 pp 651-2. Good questions: 5-1; 5-4 a, b, c; 5-5; 5-7; 5-10; 5-11; 5-12; 5-13; 5-17. I. CHROMATIN AND CHROMOSOMES Learning Objectives Understand chromatin structure. Explain how proteins and DNA interact to form chromosomes, starting with the 2nm naked DNA molecule. Be able to explain the structure of nucleosomes and the forces stabilizing these structures, then proceed to the, 10 nm fibre, higher order structures, chromosomal loops, euchromatin and heterochromatin. Understand the organization of chromosomes; describe centromere and telomere. Main Points Chromatin is a complex of DNA and protein (largely histones ). Core Histones and DNA interact to form nucleosomes . Histone H1 interacts with nucleosomes and DNA to form a native chromatin fibre. This fibre is further folded to form the interphase chormosome. Specialized parts of chromosomes (centromeres, telomeres) are formed through the interaction of specific proteins with specific DNA sequences. -
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This note was uploaded on 12/13/2011 for the course BIOLOGY 300 taught by Professor Asdf during the Spring '08 term at UBC.

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Lecture 3 Outline - BIOL 200(Section 921 Lecture 3 UNIT 3...

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