Lecture 6-7 Outline - BIOL 200(Section 921 Lecture 6/7 June 22/23 2009 UNIT 5 MEMBRANES Reading ECB(2nd ed Chap 2 pp 70-74(to review carbohydrate

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BIOL 200 (Section 921) Lecture # 6/7 June 22/23, 2009 UNIT 5: MEMBRANES Reading : ECB (2 nd ed.) Chap 2 , pp 70-74 (to review carbohydrate and lipid chemistry); Chap 11 , pp 365 –386; Chap 12 pp. 389-410 (essential) 411-421 (optional), and related questions [11-9a,b,c,d,e,f, 11-10 to 11-14, 11-17, 11-18; 12-9abce; 12-11; 12-12; 12.13; 12-15; 12-18] or ECB (1 st ed.) Chap 2 , pp 56-59 (to review carbohydrate and lipid chemistry); Chap 11 , pp 347 –368; Chap 12 pp. 371-394 (essential) 395-403 (optional), and related questions [11-9a,b,c,d,e,f, 11-10 to 11-13, 11-15, 11-18, 11-19; 12-9abce; 12-10; 12-11; 12-12; 12-14; 12-17] I. MEMBRANES: LIPIDS, LIPID BILAYERS Study Objectives: 1. Explain the condensation reactions that occur to assemble lipids and to form glycolipids 2. Explain the connection between the fluid mosaic model and the evidence supporting it. 3. Recognize that models of membranes have to be revised constantly to account for new experimental data. 4. Understand the properties and general synthesis of phospholipids, glycolipids, cholesterol, and various glycosides in membrane structure 5. Understand the properties of integral and peripheral proteins in membrane structure Classes of Membrane Lipids: 1. Phospholipids: the most abundant type of membrane lipid. Made of hydrophobic long chain fatty acid tail and hydrophilic "head". Fig. 11-6. 2. Sterols-remember that these multiring structures are formed from "isoprene" subunits and have amphipathic properties due to the OH group (see Fig. 11-7) 3. Sphingolipids- (Fig. 11-7) important in PMs , especially in the nervous system. based on the molecule sphingosine, which is derived from serine instead of glycerol. More complex than phospholipids. sphingosine + 1 fatty acid=ceramide Question: How are lipids and proteins organized within the membranes? Answer: Available data support the “Fluid Mosaic Model” (ECB, Fig. 11-4 ), proposed by Singer and Nicolson in 1972. This model depicts a fluid lipid bilayer with proteins embedded in the bilayer like icebergs in an ocean. Key Features of Fluid Mosaic Model: Membrane lipids are arranged in a bilayer
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fluid (free to move in plane of bilayer) - Experimental evidence using FRAP (Fluorescence recovery after photobleaching) technique (see course website for details of this experiment) asymmetrically arranged (different lipid components on one face of the bilayer than the
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This note was uploaded on 12/13/2011 for the course BIOLOGY 300 taught by Professor Asdf during the Spring '08 term at The University of British Columbia.

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Lecture 6-7 Outline - BIOL 200(Section 921 Lecture 6/7 June 22/23 2009 UNIT 5 MEMBRANES Reading ECB(2nd ed Chap 2 pp 70-74(to review carbohydrate

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