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Lecture 9-10 Outline

Lecture 9-10 Outline - BIOL 200(Section 921 Lecture 9/10...

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BIOL 200 (Section 921) Lecture # 9/10 June 25/26, 2009 UNIT 7: ENDOMEMBRANES Readings: ECB (2 nd ed.) Chapter 15 (Whole chapter): Introduction, pp. 496-501; Protein Sorting pp. 502- 504; Protein targeting to the Endoplasmic Reticulum, pp. 505-512; Vesicular Transport, pp. 512 – 516; Secretory Pathway, pp. 516 – 523; Endocytotic Pathway, pp. 523 -529. Questions: 15-3, 15-4, 15-6 to 15-9, 15-12, 15-13, 15-15, 15-16, 15-18, 15-19, 15-21). ECB (1 st ed.) Chapter 14 (Whole chapter): Introduction, pp. 447-452; Protein Sorting pp. 452- 455; Protein targeting to the Endoplasmic Reticulum, pp. 458-462; Vesicular Transport, pp. 462 – 466; Secretory Pathway, pp. 467 – 472; Endocytotic Pathway, pp. 472 - 477. Questions: 14-3, 14-4, 14-6 to 14-9, 14-12, 14-13, 14-15, 14-16, 14-18, 14-19, 14-21). I. Protein Targeting - Nucleus, Mitochondria, Chloroplasts and ER. Learning Objectives To explain the nature of signals and sorting To explain the function of coat proteins and the signals carried by vesicular components. To understand the role and importance of the signal recognition particle and the SRP Receptor in the targeting of proteins to the endoplasmic reticulum. To explain how single and multiple pass membrane proteins are inserted into the membrane through use of signal sequences, start transfer sequences and stop transfer sequences. Main Points: Sorting signals (signal sequence of 15-60 amino acids long) are necessary to direct a protein to a particular organelle. see Table 15-3 1. ER signal sequence-generally at N terminal, contains block of hydrophobic amino acids. 2. Nuclear localization signal-one or two short sequences with positively charged aa 3. Mitochondria/chloroplast-signal sequence at N terminal 4. KDEL-retention in the ER lumen Proteins are transported into organelles by three mechanisms (Fig:15-5)
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Lecture 9-10 Outline - BIOL 200(Section 921 Lecture 9/10...

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