MBB222-lecture6

MBB222-lecture6 - the lack of rotation around the peptide...

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Unformatted text preview: the lack of rotation around the peptide bond means that flexibility along the backbone of the protein occurs only in the bonds to the -carbon peptide backbones are free to rotate around these phi ( ) and psi ( ) bonds > allows variety in protein folding the angle of rotation about the bond between the amide N is the angle of rotation about the bond between the amide N and the C is the angle of rotation about the bond between C and the carbonyl C these two dihedral angles determine both the path of the olypeptide chain and the conformation of the peptide polypeptide chain and the conformation of the peptide backbone Are all combinations of rotational angles possible? a biochemist by the name of Ramachandran wanted to now the same thing know the same thing plotted angles vs. angles for the various amino acids (Ramachandran plot) Ramachandran Plot for L-Alanine most favoured regions: dark green - involve no steric overlap ss favoured regions: light green - lowed only at the less favoured regions: light green allowed only at the extreme limits for unfavourable atomic contacts ~ 75% of combinations are excluded because of steric interference consider the plots for other amino acids . . . roteome: Proteome: the entire protein complement of an organism humans consists of ~ 32 000 different proteins in humans, consists of 32,000 different proteins constructed from only 20 different amino acids! a protein chain folds into a unique shape / conformation stabilized by interactions between regions of the linear amino acid sequence the resulting 3-D structure is required for efficient function r any function at all, in some cases) (or any function at all, in some cases)...
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This note was uploaded on 12/13/2011 for the course MBB 201 taught by Professor -- during the Spring '11 term at Simon Fraser.

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MBB222-lecture6 - the lack of rotation around the peptide...

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