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BME365R_2006_Final_Exam

# BME365R_2006_Final_Exam - Name Final Exam Quantitative...

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Name: __________________________________ Final Exam Quantitative Physiology - BME 365R December 16, 2006 You are allowed use of a scientific calculator. Exam is closed notes and no communication with any neighboring or outside entity is allowed. Physical Constants: Planck’s Constant ( h ): 6.626·10 -34 J·s, 4.136·10 -15 eV·s Boltzman’s Constant ( k b ): 1.381·10 -23 J/K, 8.617·10 -5 eV/K Mass of the electron ( m e ): 9.109·10 -31 kg Charge on the electron ( e ): 1.602·10 -19 Coulomb One electron volt (eV): 1.602·10 -19 J Acceleration due to gravity: 10 m/s 2 Avogadro’s Number: 6.022·10 23 particles/mole Multiple Choice Questions (3 points each). In each of the following questions choose the best answer. 1. A cell has a volume of 1µm 3 , a surface area of 6 µm 2 , and a plasma membrane thickness of 10 -8 m. Outside the cell the [O 2 ] = 10 µmolar/µm 3 and inside the cell the [O 2 ] = 1 µmolar/µm 3 . Assume the permeability constant of the plasma membrane is 10 -3 µm 2 /sec and O 2 is distributed by passive diffusion. What is the flow rate [µmoles/sec] of O 2 into the cell? a. 10.1 b. 8.7 c. 6.3 d. 5.4 e. None of the above 2. A concentration cell with Ca ++ electrodes and a CaCl 2 salt bridge separates Ca ++ Cl into C 1 = 1 molar and C 2 = 0.1 molar solutions. What voltage must be applied to the cell to keep it in equilibrium? a. 60 mV b. 30 mV c. 15 mV d. 13 mV e. None of the above 3. What is the osmotic pressure generated by albumin across the blood vessel wall in your body if you assume that the albumin (solute) is impermeable and H 2 O (solvent) is freely permeable? Assume intravascular [albumin] = 4.2 gm/100ml, 10.8 meq/L, or 1.1 mOsm/L. R= 0.082 L-Atm/º- Osm and one Atm = 760 mmHg. a. 40 mmHg b. 31 mmHg c. 21 mmHg

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Name: __________________________________ d. 13 mmHg e. None of the above 4. A Gibbs-Donnan system has an initial state of [Na + Pr - ] 1 = 0.3M and [Na + Cl - ] 2 = 0.3M. What is the final state? 5. The human brain receives about what % of the cardiac output? 6. Glial cells that myelinate CNS axons are: 7. An axon has a diameter of 10µm and an axoplasmic resistivity of 30 Ω-cm and a plasma membrane resistivity of 10 9 Ω-cm. Assuming the plasma membrane is 10 -8 m thick, what is the spatial decay constant, λ. a. 1.8 mm b. 0.9 mm c. 0.5 mm d. 0.3 mm e. None of the above 8. If we assume that the membrane capacitance in the previous problem is 10 -6 F/cm 2 , then the membrane time constant, τ m , is:
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BME365R_2006_Final_Exam - Name Final Exam Quantitative...

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