3.+Kinetoplastids+Leishmania

3.+Kinetoplastids+Leishmania - The Kinetoplastids...

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Unformatted text preview: The Kinetoplastids Leishmania spp. Trypanosoma spp. * early eukaryotic lineage & one of earliest to have mitochondria single mitochondrion mitochondrial DNA is known as kinetoplast DNA network of catenated minicircles & maxicircles ~10,000 minicircles 50 maxicircles (rRNA & structural genes) The Kinetoplastid Kinetoplast huge mass of mitochondrial DNA (kDNA) electron microscopy kDNA within mitochondrion catenated minicircles & maxicircles maxicircle genes have frameshifts & lack initiation codons post transcriptional RNA modification non-encoded U residues inserted into mRNA U deletions occur at a lower frequency after transcription overcomes coding frameshifts small RNAs transcribed from maxicircles & minicircles information for insertion & deletion of Us into mRNA guide RNAs (gRNAs) gRNAs form duplexes with mRNA to provide editing information The enzymes that carry out RNA editing are unique to trypanosomes, so are an excellent future target for drugs. The Kinetoplastid & RNA Editing An edited gene showing U insertions (blue) & deletions (red) A gRNA-mRNA duplex showing information for insertions & deletions Leishmania spp. Mucocutaneous : mouth, nose, throat & skin lesions cause disfigurement. Cutaneous : papules develop into ulcers, healing with scars. Visceral : kala azar fever & enlarged spleen & liver. Fatal if not treated. Kill or Cure: Kala Azar Season 1 Episode 5 Transmitted by the bite of a sand fly, Kala Azar or visceral leishmaniasis is a deadly disease that attacks the internal organs. An estimated 1.5 million people worldwide are currently infected; 200 million people are at risk. Hopes are high in India that a new drug, paramomycin, can deliver an affordable and efficacious cure. The drug goes into production, signaling the possible elimination of this deadly disease in South Asia. http://www.rockhopper.tv/programmes/22/ Terms from the documentary-Kala Azar Bihar : state in eastern India ~ 58% of population is below age 25 has the lowest GDP /person in India per capita income of $94/year (India's average = $255) 42% population lives below poverty line Spleen : an organ that participates in filtration of RBCs and assists in developing immune response Antimony : element (Sb) used in electronics, flame-proofing, paints, rubber, ceramics, enamels & drugs to treat Leishmania infection....
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This note was uploaded on 12/13/2011 for the course BIOSCI m143 taught by Professor Staff during the Fall '11 term at UC Irvine.

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3.+Kinetoplastids+Leishmania - The Kinetoplastids...

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