Cerussi+Lecture

Cerussi+Lecture - Diffuse Optical Spectroscopic Imaging...

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Unformatted text preview: Diffuse Optical Spectroscopic Imaging (DOSI): 10 Burning Questions Albert Cerussi Beckman Laser Institute and Medical Clinic University of California, Irvine dosi.bli.uci.edu BME 135/BioSci D130 Fall, 2010 Outline Cover 10 questions that address: Diffuse Optical Spectroscopic Imaging (DOSI) Optical Imaging Biomarkers linical Applications of DOSI (breast cancer) Clinical Applications of DOSI (breast cancer) Question #1 What in the world is DOSI? What is DOSI? Diffuse Optical Spectroscopic aging Imaging NIR Broadband (650 1000 nm) high penetration in tissue What is DOSI? 10600 CO 2 LASER (nm) 20 2940 2100 2010 064 Er:YAG Ho:YAG Tm:YAG d:YAG 1 350 150 400 NIR: 1064 830 514.5 465 Nd:YAG Diode Ar Dye + 1400 1300 330 250 * 650-1000 nm 200 400 600 800 1000 1200 1400 308 248 XeCl KrF 40 5 OPTICAL PENETRATION DEPTH (microns) A. J. Welch et al., in Optical-Thermal Response of Laser-Irradiated Tissue, Plenum, pg.33 (1995). What is DOSI? 100 10 H 2 O O 2 Hb cm-1 ) NIR: * 650-1000 nm 0.1 1 HHb RPTION (c * high transparency 0.01 ABSOR 400 800 1200 1600 2000 1E-3 WAVELENGTH (nm) Wray, S., M. Cope, et al., Biochimica et Biophysica Acta 933 (1): 184-92 (1988). What is DOSI? Diffuse SOURCE DETECTOR Optical Spectroscopic aging Imaging Model based approaches What is DOSI? purely absorbing with scatter L = 1 cm L = ? What is DOSI? Diffuse Optical Spectroscopic aging Imaging Molecular targets (concentration & disposition) What is DOSI? Diffuse Medical Spectroscopy examples: Optical Pulse oximetry CO oximetry Spectroscopic Molecular assays Protein chemistry aging Imaging Molecular targets (concentration & disposition) What is DOSI? Diffuse Optical Spectroscopic aging Imaging Current: 2D mapping (no tomography) What is DOSI? Diffuse Medical Imaging examples: Optical Ultrasound X ray (mammography) STRUCTURE Spectroscopic CT MRI ET aging PET MRS FUNCTION Imaging Current: 2D mapping (no tomography) Question #2 What does DOSI measure? What does DOSI measure?...
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Cerussi+Lecture - Diffuse Optical Spectroscopic Imaging...

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