Lecture-6-kscN152

Lecture-6-kscN152 - 10/10/11! Developmental Neurobiology!...

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10/10/11 1 Karina S. Cramer cramerk@uci.edu 10/11/11 Developmental Neurobiology N152 Neuronal Migration – key points • Neural crest migration gives rise to the peripheral nervous system and has segment specifcity • In the CNS, cells undergo migration at the ventricular zone during a process called interkinetic nuclear migration
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10/10/11 2 Neuronal Migration – key points New neurons migrate along radial glial cells as they move toward the cortical plate. Neuronal Migration – key points Radial glia are progenitors for neurons and glia
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10/10/11 3 Neuronal Migration – key points Migration along glial cells occurs radially and tangentially Migration along glial cells happens in many areas of developing nervous system. Neuronal Migration – key points Migration is seen in several secondary zones of neurogenesis (i.e., neurogenesis in cells that have moved away from the ventricular zone) These areas have been found to have some limited neurogenesis in adults External granule cell layer of cerebellum Subventricular zone: wall of lateral ventricle Hippocampus Adult retina in amphibians
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10/10/11 4 Outline: Neuronal fate speciFcation • Cell fate speciFcation: further interactions that lead to formation of distinct cell types. • Tools for studying this process include genetics, transplantation, and co-cultures. • Mosaic development (as in C. elegans) occurs when different neurons derive from different precursor with very limited potential. • Patterns of gene expression along the axes (see lecture 2) lead to changes in gene expression that in±uence cell fate. • Timing matters: different factors change their expression over time, so that progeny have different fates depending on when they were born. • Cell-cell interactions provide signals that in±uence cell fate. • Some progenitors in vertebrates have multiple possible fates, and the factors that determine several of their choices have been identiFed. Mutational analysis Forward genetics : Identify new genes that have effects on neural differentiation Reverse genetics : molecular engineering to knock out or over express genes that are candidates for roles in neuronal fate determination or differentiation Testing Cell ²ate
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5 Figure 22-7 Molecular Biology of the Cell (© Garland Science 2008) Tissue transplants to examine whether a cell ` s fate is determined Figure 22-7 Molecular Biology of the Cell (© Garland Science 2008) Tissue transplants to examine timing of determination • Transplantation studies can also be used to ascertain when cell fate determination occurs. Heterochronic transplants to a homologous location can be used to test competence at different times. • Depends on when factors are released, and when cells are competent to
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lecture-6-kscN152 - 10/10/11! Developmental Neurobiology!...

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