Lecture+1+partB+color

Lecture+1+partB+color - 10/31/2011 1 Axon Growth and...

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Unformatted text preview: 10/31/2011 1 Axon Growth and Guidance November 1, 2011 Developmental Neuroscience Developmental Neuroscience BioSci BioSci N152 N152 Developmental Neuroscience Developmental Neuroscience BioSci BioSci N152 N152 Website: Website: https://eee.uci.edu/11f/06211 Chapter 5 Dev. of the Nervous System Sanes, Reh & Harris Susana Cohen-Cory, Ph.D. Neurobiology and Behavior Office: 1230 McGaugh Hall X 48188 e-mail: scohenco@uci.edu Molecules and Mechanisms Molecules and Mechanisms Involved in Axon Guidance Involved in Axon Guidance Contact mediated Contact mediated Soluble signals Soluble signals 10/31/2011 2 Extracellular matrix adhesion Extracellular matrix adhesion Fasciculation Fasciculation Pioneer neuron Pioneer neuron Long Long range cues range cues Chemorepulsion--- Chemoattraction + + + + + Short Short range cues range cues--- Contact attraction Contact repulsion 10/31/2011 3 Molecular cues Long range attraction: Growth cones may exhibit positive chemotaxis behavior to certain DIFFUSIBLE molecules originating at distant sources and grow towards these molecules (green here) Long range repulsion: Growth cones may exhibit negative chemotaxis to diffusible molecules and orient themselves away (red here) Adhesion Growth cones have different morphologies depending upon the substrate that they are growing on Neurites tend to follow more adhesive paths BUT if it is too sticky where the filopodia cannot retract, then the growth cone slows down (e.g. lectin concanavalin A) 10/31/2011 4 Extracellular matrix proteins Laminin, collagen, fibronectin, etc. ECM proteins are large proteins They have different functional domains ECM proteins are large proteins. They have different functional domains for cell attachment, for attachment to the substrate and for protein interactions Vertebrate CNS neurons grow better on laminin while peripheral neurons prefer to grow on fibronectin When retinal neurons are given a choice between laminin and fibronectin When retinal neurons are given a choice between laminin and fibronectin (laid down in stripes stripe assay), retinal axons prefer to grow on laminin, though they will grow on either substrate if given no choice Extracellular matrix proteins Non Non-adhesive adhesive substrate substrate Laminin Laminin 10/31/2011 5 Integrins Integrins: Receptors for ECM proteins : Receptors for ECM proteins...
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lecture+1+partB+color - 10/31/2011 1 Axon Growth and...

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