Lecture+5+Notes

Lecture+5+Notes - Developmental Neurobiology! N152! Karina...

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1 Karina S. Cramer [email protected] 10/6/11 Developmental Neurobiology N152 Neurogenesis - Summary Birthdating studies help us determine when neurons were born, or underwent fnal mitotic division. The location and time that neurons are born determines their Fate. Location is related to regionalized signals Time is related to signals and to potential CNS shows clusters oF similar cells with similar birthdates and places.
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2 Birthdating studies: chick auditory brainstem NL NM NM NL Rubel, Smith, and Miller, 1976 Injection at 2.5 Days Injection at 3.5 Days NM and NL cells labeled at E13 NM cells more intensely labeled Most NL cells labeled NM cells not labeled Conclusion : NM cells are born between E2.5 and E3.5. NL cells are born after E3.5. Neurogenesis - Summary Neurogenesis occurs at the ventricular zone. Early divisions are symmetric, later divisions are asymmetric. Neurogenesis is regulated by factors that control the cell cycle.
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3 Interkinetic Nuclear Migration Taverna and Huttner, Neuron 67, 2010 Cell lineages in the CNS Early l founder z cells may make more restricted progenitors, which make fewer progeny. Lineage relationships may vary in different regions of the CNS. Clonal analysis has helped identify lineages.
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4 Neurogenesis - Summary Proneural genes promote neuronal fate, suppress glial fate. Wnt, neurogenin 1 and 2 Sequence of transcription factors relates to developmental stage Neuronal Migration Neurons are generated in a limited number of places, but need to move to appropriate location to form nuclei, circuits, etc. Occurs in both central and peripheral nervous system: The neural crest contains distinct migratory streams that follow stereotyped tragectories. Migration proceeds in an orderly way to generate layers of cells and proper cell types in the CNS. Intercellular signaling molecules and neuron-glial interactions facilitate migration.
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5 Figure 22-97 Molecular Biology of the Cell (© Garland Science 2008) Neural Crest Migration Neural crest cells are found at the dorsal surface at the time of neural tube closure. Neural crest cells then undergo extensive migration to many areas within the body. These cells give rise to the peripheral nervous system, along with several other tissues. Marmigère and Ernfors Nature Reviews Neuroscience 8 , 114–127 (February 2007) | doi:10.1038/nrn2057 Ventral pathway: dorsal root ganglia (DRG; sensory lineage), and sympathetic and enteric neurons (autonomic lineage). Dorsolateral pathway: pigment cells (melanocytes) in skin. After forming DRG, NCCs form principal sensory subtypes such as nociceptive, mechanoreceptive and proprioceptive neurons. " fter neuronal subtypes are specified,
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lecture+5+Notes - Developmental Neurobiology! N152! Karina...

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