Lecture+Syn+Form+2+B+W

Lecture+Syn+Form+2+B+W - 11/9/2011 Synapse Formation and...

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11/9/2011 1 Synapse Formation and Function November 10, 2011 Chapter 8 Dev. of the Nervous System Susana Cohen-Cory, Ph.D. Neurobiology and Behavior Office: 1230 McGaugh Hall X 48188 e-mail: scohenco@uci.edu You left home Headed to Campus Drove your car through busy freeways/streets or biked your way here. Looked and gambled for a parking spot Parked far from the building Walked to Hewitt Hall Found your way to the classroom Found your sea Found your seat Now, you need to activate your synapses to receive and transfer information within the class environment.
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11/9/2011 2 Forming functional connections between nerve cells distinguishes neural development from other tissues P b i ith l th f ll i t f t ll l Process begins with axonal growth cones following a set of extracellular cues to reach precise location within a distant target (Chapter 5 and 6) When the growth cone finally contacts with an appropriate postsynaptic cell, it needs to decide whether to stop growing and differentiate into a presynaptic terminal. How many neurons are there in a human brain? How many synapses are made in a human brain? 100 billion (100,000,000,000) 15 How do you achieve synaptic specificity? 1 quadrillion synapses (10 or 1,000,000,000,000,000) Tightly controlled developmental processes
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11/9/2011 3 Synapse formation Synapse refinement Activity-dependent remodeling of synaptic contacts Measuring synapse number How can you tell when new synapses are formed? Electrophysiological recordings
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lecture+Syn+Form+2+B+W - 11/9/2011 Synapse Formation and...

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