Lecture8Notes

Lecture8Notes - Developmental Neurobiology N152 Karina S Cramer [email protected] My office hours this week TUESDAY October 18 1:30 pm 2:30 pm 2205

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10/17/11 1 Karina S. Cramer [email protected] 10/18/11 Developmental Neurobiology N152 My office hours this week: TUESDAY October 18 1:30 pm – 2:30 pm 2205 McGaugh Hall Thursday, October 20: Ana will lead review session for midterm.
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10/17/11 2 Dying Cells • Apoptosis, or programmed cell death, occurs as part of normal development in the retina. • Cells undergoing apoptosis appear rounded, smaller, and have chromatin in the nuclei. • Electron microscopy shows pyknotic nuclei, with fragmented chromosomes. • Pyknosis: marked by clumped chromosomes, shrinking of nucleus, dark color. • Small apoptotic bodies bud off ( l blebbing z ) and are phagocytosed by macrophages. • Requires the cell to l actively z die through gene transcription and protein synthesis • Cells become condensed and aggregates at the nuclear membrane • Plasma membrane remains intact but the neuron gradually shrinks • TUNEL labeling labels nicked ends of DNA; other markers are also available. • Need to meet morphological criteria Apoptosis
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10/17/11 3 Does the target influence cell proliferation or cell death? • Since neurogenesis is one method for regulating cell numbers and cell death is another. .. • Viktor Hamburger and Rita Levi- Montalcini demonstrated that removing the target leads to an increase in the number of dying neurons • One wing bud was removed at about 3 days of incubation and the
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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Lecture8Notes - Developmental Neurobiology N152 Karina S Cramer [email protected] My office hours this week TUESDAY October 18 1:30 pm 2:30 pm 2205

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