McGaugh+PPT - No Treatment GABAergic antagonists:...

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Unformatted text preview: No Treatment GABAergic antagonists: picrotoxin, bicuculline D-amphetamine, strychnine Memory is assisted by anything that makes an impression on a powerful passion, inspiring fear, for example, or wonder, shame or joy. Francis Bacon, 1620 Inhibitory Avoidance 100 50 200 0 250 150 0 10 30 120 Time of Posttraining Injection (min) Gold and van Buskirk, 1975 100 50 200 0 250 150 0 10 30 120 Time of Posttraining Injection (min) Gold and van Buskirk, 1975 200 100 400 0 600 300 Inhibitory Avoidance Retention Latencies Liang, Juler and McGaugh, 1986 500 Epinephrine i.p. Saline i.p. Propranolol Infused into Amygdala 50 100 150 200 250 300 Latency (s) 4 8 12 16 20 % freezing 40 80 120 160 200 Latency freezing Vehicle-control NE (0.3 g) NE (1.0 g) shock training No-shock controls No-shock controls No-shock controls shock training shock training LaLumiere, Buen & McGaugh 2003 10 20 30 40 50 60 Posttraining NE BLA infusions enhance extinction 0.3 g Saline Freezing (s) 1.0 g * Norepinephrine Saline 1.0 g NE No Extinction Interval A3 ?...
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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McGaugh+PPT - No Treatment GABAergic antagonists:...

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