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N112a-AlzheimerDisease-2011

N112a-AlzheimerDisease-2011 - Alzheimers disease I...

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Alzheimer’s disease I: Molecular and cellular approaches N112a 11/16/11 Mathew Blurton-Jones [email protected]
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Memory impairments can occur as a part of many disorders Parkinson Disease Dementia with Lewy Bodies Huntington Disease Traumatic Brian Injury Stroke Alzheimer Disease
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Outline What is Alzheimer Disease (AD) AD prevalence, neuropathology Mouse models of AD What have AD mouse models taught us? Alternative approaches to study AD
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Alois Alzheimer 1864-1915 November 6, 1906 A Peculiar Disease of the Cerebral Cortex
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Auguste D Photo dated November, 1902 “I have lost myself.”
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Alzheimer Disease (AD) Alzheimer disease is an age-related progressive brain disorder that gradually destroys a person’s memory and ability to learn, reason, make judgments, communicate and carry out daily activities.
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AD Risk Factors Advancing age Susceptibility/risk genes Family history of dementia Previous head trauma Low education level Down syndrome Diet and other environmental factors
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Why is the incidence of Alzheimer’s disease increasing so much?
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