N152Midterm2010KEY - Bio Sci N152, Fall 2010 Midterm NAME:...

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1 Bio Sci N152, Fall 2010 Midterm NAME: Key STUDENT ID NUMBER: __________________________________________ Part I--Short Answer (each question is worth 1 point) 1. Name one secondary zone of neurogenesis: SVZ/hippocampus/external granule cell layer (cerebellum) 2. BMPs secreted from the dorsal aorta induce neural crest progenitors into sympathetic neurons. Half credit: NGF, neurotrophins 3. In C. elegans , the term mosaic development refers to the observation that when neural progenitors are ablated all of the neurons from that lineage are lost and cannot be replaced. Also accepted: stereotyped, determined, invariant 4. Naturally occurring programmed cell death is called apoptosis . 5. The embryonic process that leads to the formation of three germ layers is called gastrulation . 6. The organizer in chick embryos that most closely resembles Spemann’s organizer is called Hensen’s node . 7. The “default” fate for ectodermal tissue is neural tissue ; however, in some tissues this fate is normally inhibited by BMP . 8. In the vertebrate nervous system, levels of which diffusible factor regulate hox gene expression? Retinoic acid or FGF. Half Credit: Pbx 9. Neurogenesis gives rise to neurons and glia . 10. “Birthdating” studies provide information on when neurons underwent their final mitotic division. What is the best experimental approach to identify the birthdates of neurons? Tritiated thymidine/BrdU/retroviral labeling 11. The temporally coordinated expression sequence of transcription factors such as hunchback and krueppel in drosophila neuroblasts depends on cell cycle . Also accepted: asymmetric cell division, bHLHs, GMC, space and time, numb and prospero. Half credit: space, timing, hox genes, cell-cell communication, phosphorylation 12. The Boss gene is expressed in photoreceptor 8 and encodes a ligand for Sevenless, a receptor tyrosine kinase. Null mutations in Boss result in a loss of which cell types in the drosophila eye? R7s. Also accepted: photoreceptor, rod, UV-sensitive cells 13. Name a morphogen that specifies the dorsoventral axis: Shh/BMP/wnt/FGF/RA/etc.
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2 Part II--Multiple Choice (each question is worth 1 point) 1. Transplantation of a Xenopus Spemann organizer to the opposite side of an age- matched Xenopus host is what type of manipulation? a. isochronic and homotopic b. isochronic and heterotopic c. heterochronic and homotopic d. heterochronic and heterotopic e. none of the above 2. Which of the following organisms has an entirely stereotyped cell lineage that has been characterized? a. Drosophila melanogaster b. Caenorhabditis elegans c. Xenopus laevis d. Danio rerio e. Mus musculus 3. A candidate molecule is added to an animal cap. Mesoderm tissue is first induced and then neural tissue. The candidate molecule is what? a.
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This note was uploaded on 12/13/2011 for the course BIOSCI 93 taught by Professor Staff during the Fall '11 term at UC Irvine.

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N152Midterm2010KEY - Bio Sci N152, Fall 2010 Midterm NAME:...

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