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Wood+Lecture+6+Notes

Wood+Lecture+6+Notes - truncation(Oike et al 1999 •...

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1 Rubinstein-Taybi Syndrome (RTS) is a human disease characterized by mental retardation and developmental abnormalities (Rubinstein and Taybi 1963; Cantani and Gagliesi 1998) Two mouse models of RTS generated •1) conventional CBP knockout: heterozygous null mutation (Tanaka et al., 1997) •2) insertional mutation: CBP C-terminal
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Unformatted text preview: truncation (Oike et al., 1999) • C-terminal truncation expressing mice have most signiFcant phenotypic overlap with RTS patients Are CBP and histone acetylation involved in memory storage? 2 Cre-Recombinase System 3 4 5 Novel object recognition Training: 1 Trial (3 or 10 Mins) A A Testing: 1 Trial (5 Mins) A B...
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