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Unformatted text preview: 1 Prader Willi Prader Willi Syndrome Syndrome 1/10,000 births = 1,600 in US 1/10,000 births = 1,600 in US Diminished fetal Diminished fetal activity activity *Obesity - *Obesity - hyperphagia hyperphagia *Moderate mental *Moderate mental retardation retardation *Short stature *Short stature *Hypogonadism Hypogonadism *Smal hands and feet *Smal hands and feet *Hypopigmentation Hypopigmentation *Facies Facies with narrow with narrow bifrontal bifrontal diameter, diameter, almond eyes, ful almond eyes, ful cheeks cheeks 9.5 yrs 9.5 yrs Happy puppet ( Angelman) syndrome *Severe mental retardation *Motor retardation - ataxia, hypotonia *Epilepsy *Absence of speech *Facies - large mandible, open mouth, tongue thrusting *Hypopigmentation *Frequent, excessive prolonged laughter Angelman syndrome aka Happy puppet syndrome zygote. zygote. swarthmore swarthmore . edu edu / chrom3a.html / chrom3a.html Angelman Prader willi Angelman Prader willi Both genes map close to one another on...
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This note was uploaded on 12/13/2011 for the course BIOSCI 137 taught by Professor Staff during the Fall '11 term at UC Irvine.
- Fall '11