PS2-11x - Bio D137 Human Eukaryotic Genetics J.L. Marsh F11...

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1 Bio D137 Human Eukaryotic Genetics J.L. Marsh F’11 PROBLEM SET #2 DUE Tues 10/4 by 4pm in the box, 5 th floor MH 1]. In the following pedigrees, assume that the disease trait is rare in the population. Answer the following questions about each pedigree: a] What is the probable mode of inheritance for family 1 and for family 2 ie. Dominant or recessive? Why? b] What are the possible genotypes of individuals X and Y in each pedigree? [1] [2] X Y X Y 2] Achromatopsia ( ACHM ), is a medical syndrome that describes a color vision disorder, i.e. the inability to perceive any color and to achieve satisfactory visual acuity at high light levels (typically exterior daylight). Due to a founder effect, a large fraction of the population of Pingelap suffers from this syndrome as illustrated by Oliver Sacks in the book “ The Island of the Colorblind ”. A study was conducted of a 90 pairs of twins found by identifying one twin with the visual defect and in all these families neither parent was affected. 30 of the twins proved to be monzygotic twins and in all these 30 cases both twins suffered from ACHM. Of the 60 families with dizygotic twins, 14 cases were recorded where the second twin was affected. A] What does this suggest about the mode of
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PS2-11x - Bio D137 Human Eukaryotic Genetics J.L. Marsh F11...

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