PS5-11 - Bio D137 Human and Eukaryotic Genetics Prob Set 5...

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Bio D137 Human and Eukaryotic Genetics J.L.Marsh F'11 Prob Set 5 due Oct, 28 Name/student ID:_______________ 1 1 1] Several enzymes and proteins a, b, c, d, e, f are known to be coded in a region near a locus of interest on chromosome 22 in humans, but their order is unknown. Patients with sporadic symptoms were analyzed and karyotyping identified 5 patients with deficiencies (deletions) on this arm of chromosome 22. The level of gene product being expressed was determined using biochemical and immunological techniques. The level of gene activity is indicated below as a percent relative to the activity observed in non-deletion bearing control persons. The data are: a b c d e f Pt 1 57 101 103 51 46 53 Pt 2 52 98 101 105 51 99 Pt 3 48 52 50 103 49 52 Pt 4 95 98 46 96 52 99 Pt 5 103 51 52 100 57 102 a) Use these data to determine the order of these genes on chromosome 22. b) What gene most likely is responsible for the disease? 2] Zohary and Brown discovered a long inversion in a lily species and cytologically studied plants heterozygous for the inversion. They found 252 cells in diakinesis with one chiasma in the inversion and one chiasma outside of the inversion.
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