PS6-11 - Bio D137 Human and Eukaryotic Genetics Prob Set 6...

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Bio D137 Human and Eukaryotic Genetics J.L.Marsh F'11 Prob Set 6 due Tues, Nov 8 Name/student ID:_______________ 1 1 1] One copy of the long arm of chromosome 18 leads to early postnatal death, and three copies leads to Edward's syndrome (retardation, cleft lip & palate, short thumb, odd shaped head and others). Patients are difficult to feed and usually die before 1 year. Suppose that a reciprocal translocation occurs in a diploid sperm precursor cell with the two breaks being one near the centromere of 18q and the other near the teleomere of 10q. This sperm precursor cell then undergoes meiosis to produce four sperm cells. a] Draw the pairing configuration of chromosomes 18 and 10 at prophase 1 of meiosis. Label everything. b] Using a punnet square diagram the chromosome unions possible if the meiotic products from such a sperm cell were to fertilize a normal egg. c] What phenotypes, and in what proportions, would you expect with the chromosome constitutions you described in b above. 2] In humans, chromosome 18 is best known for its involvement in ring chromosomes although
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This note was uploaded on 12/13/2011 for the course BIOSCI 137 taught by Professor Staff during the Fall '11 term at UC Irvine.

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PS6-11 - Bio D137 Human and Eukaryotic Genetics Prob Set 6...

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