PS7b-11Blast+prob-2 - Bio D137 Human and Eukaryotic...

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1 Bio D137 Human and Eukaryotic Genetics Problem Set #7b J. L. Marsh Fall 2011 Due 11/21/11 Scoring: 6.5 points total. If you attempted an answer for each question you automatically got 0.5 points for each question. Using information from model organisms such as Drosophila to better understand human genes and their function is a very powerful tool. Familiarity with web based tools and genbank is useful to you as a scientist, as a medical practitioner and as an informed person who may want to find accurate information about genes in the future. The objective of this problem is to give you a quick tour of some of the most powerful things that GenBank can do for you. I encourage you to explore as you do this problem. In class, we discussed the two major strategies for cloning a gene, namely positional cloning and targeted cloning , and we discussed the utility of using genes described in model organisms to find important human genes. Mutations in the Drosophila patched gene exhibit a segment polarity phenotype and other defects suggestive of a role in modulating signal transduction between cells. The protein sequence is shown below. Please use this protein sequence to determine if there is a human counterpart of this protein, how related it is and whether there might be any reported mutations in this gene. Note: I have posted this sequence in a word document on the class web site so you can cut and paste it as needed. >gi|8390|emb|CAA35591.1| patched protein [Drosophila melanogaster] MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLST FCVGLKSAQIHSKVHQLWIQEGGGLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWG
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This note was uploaded on 12/13/2011 for the course BIOSCI 137 taught by Professor Staff during the Fall '11 term at UC Irvine.

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PS7b-11Blast+prob-2 - Bio D137 Human and Eukaryotic...

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