PS7b-11Blast+prob+

PS7b-11Blast+prob+ - Bio D137 Human and Eukaryotic Genetics...

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1 Bio D137 Human and Eukaryotic Genetics Problem Set #6b J. L. Marsh Fall 2011 Due 11/21/11 Using information from model organisms such as Drosophila to better understand human genes and their function is a very powerful tool. Familiarity with web based tools and genbank is useful to you as a scientist, as a medical practitioner and as an informed person who may want to find accurate information about genes in the future. The objective of this problem is to give you a quick tour of some of the most powerful things that GenBank can do for you. I encourage you to explore as you do this problem. In class, we discussed the two major strategies for cloning a gene, namely positional cloning and targeted cloning , and we discussed the utility of using genes described in model organisms to find important human genes. Mutations in the Drosophila patched gene exhibit a segment polarity phenotype and other defects suggestive of a role in modulating signal transduction between cells. The protein sequence is shown below. Please use this protein sequence to determine if there is a human counterpart of this protein, how related it is and whether there might be any reported mutations in this gene. Note: I have posted this
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This note was uploaded on 12/13/2011 for the course BIOSCI 137 taught by Professor Staff during the Fall '11 term at UC Irvine.

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PS7b-11Blast+prob+ - Bio D137 Human and Eukaryotic Genetics...

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