chap 7 powerpoint gray

chap 7 powerpoint gray - Hypersensitivities,Infection

Info iconThis preview shows pages 1–20. Sign up to view the full content.

View Full Document Right Arrow Icon
Hypersensitivities, Infection  Hypersensitivities, Infection  and Immune Deficiencies and Immune Deficiencies Chapter 7
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Immune System “protects against foreign antigens” Inappropriate Exaggerated – allergy Misdirected – autoimmunity Against beneficial foreign tissue – alloimmunity Insufficient – immune deficiency 
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hypersensitivity   Allergy Deleterious effects of hypersensitivity to environmental  (exogenous) antigens Autoimmunity Disturbance in the immunologic tolerance of self- antigens (autoantibodies) Alloimmunity Immune reaction to tissue of another individual 
Background image of page 4
Hypersensitivity   Characterized by the immune mechanism Type I IgE mediated Type II Tissue-specific reaction Type III Immune-complex mediate Type IV Cell mediated
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mechanisms of Hypersensitivity “require sensitization against Ag from a 1°  immune response” “disease symptoms after 2° immune response” Immediate – minutes to hours Delayed – hours to days
Background image of page 6
Type I Hypersensitivity   IgE mediated Environmental antigens (allergens) IgE binds to Fc receptor on a mast cell Histamine release H 1  receptors antihistamines
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Type I    Genetic predisposition Tests Food Skin  Lab (IqE)  Desensitization IgG – blocking antibodies 
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Type I Hypersensitivity Type I Hypersensitivity
Background image of page 10
Type II Hypersensitivity  - autoimmune  Tissue specific Cells or tissue  (tissue-specific Ag) – target of an  immune response
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Type II   Five mechanisms Cellular destruction – Ab + Complement Phagocytosis Neutrophil-mediated damage to tissue Antibody dependent cell mediated cytotoxicity (NK  cells) Target cell malfunction 
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Type III Hypersensitivity   Immune complexes (Ag – Ab cplx) Formed in the circulation    vessel walls or  extravascular tissue   C3b + neutrophils   tissue  damage SLE, serum sickness, Raynaud phenomenon 
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Type IV Hypersensitivity   Cytotic T-lymphocytes  or  Th 1  cells – lymphokine Direct killing or phagocytosis Examples  Acute graft rejection TB skin test, contact allergic  reactions (poison ivy) Type II collagen   rheumatoid arthritis thyroid cell surface   Hashimoto disease  Pancreas   diabetes Type I
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Allergy Environmental antigens that cause atypical  immunologic response – genetically predisposed  individuals Pollens, molds, fungi, foods, animals, dust Allergen is contained within a particle too large  to be phagocytosed or is protected by a  nonallagenic coat
Background image of page 18
Autoimmunity Loss of Tolerance Views self as foreign Examples  Acute rheumatic fever – group A streptococcal sore 
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 20
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/14/2011 for the course AC 100 taught by Professor Strickland during the Spring '11 term at Alabama.

Page1 / 61

chap 7 powerpoint gray - Hypersensitivities,Infection

This preview shows document pages 1 - 20. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online