networks - Introduction to Cellular Networks BMI/CS 576

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Introduction to Cellular Networks BMI/CS 576 www.biostat.wisc.edu/bmi576/ Mark Craven craven@biostat.wisc.edu Fall 2011 Various subnetworks within cells metabolic : describe reactions through which enzymes convert substrates to products regulatory : describe interactions that control expression of particular genes signaling : describe interactions among proteins and small molecules that relay signals from outside the cell to the nucleus note: these networks are linked together and the boundaries among them are not crisp
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gene products other molecules Figure from KEGG database Part of the E. coli regulatory network Figure from Wei et al., Biochemical Journal 2004
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A signaling network Figure from Sachs et al., Science 2005 Two key tasks learning : given background knowledge and high- throughput data, try to infer the (partial) structure/ parameters of a network inference : given a (partial) network model, use it to predict an outcome of biological interest (e.g. will the
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networks - Introduction to Cellular Networks BMI/CS 576

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