113lecture3606 - BIOLOGY 113 - MICROBIOLOGY Lecture 36:...

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BIOLOGY 113 - MICROBIOLOGY Lecture 36: Microbial Diseases of the Digestive System - Viral, protozoan and helminthic infections Mumps begins with infection and inflammation of the paratid glands , which are one of three pairs of salivary glands - The agent is a paramyxovirus , the same group to which measles virus belongs - Mumps virus uses the respiratory tract as portal of entry, gaining access to the paratid glands (and other tissues) following transient viremia - The main complications of mumps involve inflammatory damage to testes, meninges, ovaries or pancreas - An effective attenuated vaccine, administered as part of the MMR vaccine, has dramatically reduced the incidence of mumps Cytomegalovirus (CMV) is a herpesvirus that causes infections that are usually subclinical (Tortora et al., Figure 25.13) - Infection with CMV is extremely common, with a high percentage of persons showing serological evidence of having been infected - Like other herpesviruses, CMV persists for life; macrophages are an important site of latency - Although infection with CMV is usually mild, it can be damaging in particular circumstances = Primary infection of a pregnant woman can lead to congenital cytomegalic inclusion disease in the developing fetus, a major cause of congenital mental damage = CMV is frequently transmitted by transplanted tissues, and can cause a severe systemic
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This note was uploaded on 12/15/2011 for the course BIO 113 taught by Professor Staff during the Fall '11 term at Wilkes.

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113lecture3606 - BIOLOGY 113 - MICROBIOLOGY Lecture 36:...

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