multi-center safety trial

multi-center safety trial - multicenter inv 28 28 28 28 28...

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Unformatted text preview: multicenter inv 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 patient visit 4261 4261 4261 4261 4261 4262 4262 4262 4262 4262 4264 4264 4264 4264 4264 4265 4265 4265 4267 4267 4269 4269 4269 4269 4269 4271 4271 4271 4271 4271 4272 4273 4273 4273 4273 4273 4275 4275 4275 4276 4276 4276 4276 4276 4277 4277 4277 4277 4277 4280 4280 4280 week 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 1 2 3 4 5 1 2 3 4 5 1 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 0 3 6 9 12 0 3 6 9 12 0 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 day_pain reg_dsev rts_dsev 0.5 1 0.25 0 0 0 0 0 0 0 1.25 4 0.5 1 0.5 1 epi_dsev htb_dsev weightkg 0 1 75.91 0 1 77.27 0 0 77.73 0 0 77.73 0 0 77.27 0 1 99.09 0 1 101.59 1 0 99.09 0 0 0 0 0 0 0 0 0.5 1 0.75 0.25 0 2.25 0.5 1.25 1.25 1.75 1.25 0.75 0.5 0.5 0.75 2 2 0 0 0 1.25 2 1 1 1 0.5 2.25 1 1.25 3 1 1 1.25 0.75 1.25 1.25 1.25 1.5 1 0.5 1.25 0.5 1 2 0 0 0 3 1 1 1 1 2 1 0 0 1 2 2 0 0 0 0.5 1 1 2 2 1 3 1 1 3 1 1 1 1 2 1 1 1 1 0 1 0 0 0 1 0 0 3 0 0 3 3 0 1 1 1 1 3 2 0 0 0 0 3 1 0 0 0 2 1 1 3 1 1 2 1 0 0 0 2 1 0 1 0 0 0 1 0 0 0 0 3 0 0 0 0 0 0 0 2 2 0 0 0 1.5 1 1 0 0 0 3 1 2 3 1 1 1 0 2 2 2 2 1 0 1 0 1 2 1 1 0 3 1 1 1 3 3 1 1 1 1 1 2 0 0 0 3 3 1 2 2 1 1 1 1 3 1 1 1 1 1 2 2 1 1 2 2 2 71.36 70.91 72.73 72.73 70.91 107.73 106.82 107.27 107.73 107.27 81.36 80.91 81.59 80.46 61.36 61.36 64.09 62.27 68.18 75 74.09 75.46 76.82 77.27 94.09 94.55 94.09 62.96 63.18 64.09 70.45 72.27 70.45 71.36 69.55 87.73 87.73 88.18 Page 1 multicenter 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 37 37 37 40 4280 4280 4401 4401 4401 4401 4401 4403 4403 4403 4404 4405 4405 4405 4405 4405 4406 4406 4406 4406 4406 4408 4408 4410 4410 4410 4412 4412 4412 4413 4413 4413 4415 4415 4415 4416 4416 4416 4416 4417 4417 4417 4417 4417 4418 4418 4418 4418 4418 4121 4121 4121 3082 4 5 1 2 3 4 5 1 2 3 1 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 4 1 2 3 4 5 1 2 3 4 5 1 2 3 1 9 12 0 3 6 9 12 0 3 6 0 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 0 3 6 0 3 6 0 3 6 0 3 6 9 0 3 6 9 12 0 3 6 9 12 0 3 6 0 0.75 0.5 1.5 1 0.25 0.5 0.25 1.75 0.75 0.5 1.25 0.75 0.75 1.25 0.5 0 1 1 1.25 1 1 2 3 1.5 1 1 1.5 0.5 0.25 3 1 1.5 1.75 0.25 1.5 2 1.5 1.25 1.75 2.25 0 0 0 0 1 1.5 0.75 0.75 0.75 2.25 2.5 2 1.25 1 0 2 2 0 1 0 2 0 0 1.5 0 1 0 0 0 1 0 1 0 0 1 3 3 1 1 3 1 0 3 1 1 3 0 1 2 2 1 1 3 0 0 0 0 2 2 1 1 1 3 3 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 3 0 1 1 1 0 0 3 1 0 0 0 1 3 0 0 0 1 0 0 0 0 0 2 1 1 1 2 2 2 0 0 0 2 0 0 0 0 3 2 2 1 1 0 3 0 0 0 2 2 2 2 3 3 0 0 0 0 0 0 2 1 2 2 0 1 1 2 2 3 2 0 0 0 0 0 0 0 0 0 2 3 2 1 2 2 2 2 1 1 1 2 1 0 2.5 2 2 2 2 0 2 2 2 2 2 2 3 3 2 2 2 1 1 4 1 3 2 1 3 2 2 2 3 3 0 0 0 0 2 2 1 1 1 2 2 1 3 89.09 88.18 81.36 85.91 83.64 85.45 86.36 73.18 73.18 73.64 85 61.36 64.55 63.64 65.45 63.64 73.64 75.91 75.91 76.36 76.73 81.82 85.91 80.91 80 81.82 74.32 74.55 74.55 70.45 71.82 71.36 95.45 97.27 65.91 65.45 66.82 67.73 68.64 69.09 68.64 69.09 68.18 75 74.77 71.82 70.91 77.27 77.27 78.18 88.64 Page 2 multicenter 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40 41 41 41 41 41 41 41 41 41 41 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43 46 46 46 46 46 46 46 46 46 46 46 46 46 3082 3082 3082 3083 3083 3083 3083 3084 3084 3084 3085 3085 3085 3085 3085 3161 3161 3161 3161 3161 3162 3162 3162 3162 3162 3461 3461 3461 3461 3461 3462 3462 3462 3462 3462 3464 3464 3464 3464 3464 3641 3641 3641 3641 3641 3643 3643 3643 3643 3643 3644 3644 3644 2 3 4 1 2 3 4 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 3 6 9 0 3 6 9 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 1.75 1.25 1 0.5 0.25 0 0 1 0.25 0 1.25 0.5 0.5 2.5 0.75 0.5 0.25 0.25 0.25 0.5 0.75 0 0.5 0 0 1.25 0.25 0.25 0.25 0.25 1.75 0.75 1.5 1 0 0.75 0.5 0.5 0.75 0.5 2 1 1.25 0.5 1.25 4 2.25 0.75 0.75 0.5 1.25 0.5 0.5 1 1 1 2 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 3 0 3 1 0 0 0 0 0 0 3 0 1 0 1 4 2 1 1 1 1 0 0 1 2 1 0 0 0 0 0 0 0 2 1 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 1 4 2 0 0 0 2 1 0 4 1 1 0 0 0 0 2 0 0 0 1 1 4 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 1 1 0 0 2 0 0 0 0 1 2 2 1 2 4 1 0 1 0 2 1 0 1 1 1 0 1 0 0 2 1 0 3 0 0 3 2 2 1 1 1 2 1 0 1 0 0 2 1 1 1 1 1 2 2 3 0 1 2 2 3 2 3 2 2 1 1 4 4 2 1 1 0 0 2 88.64 88.18 89.09 82.27 89.09 85 81.82 60 60 61.36 81.82 82.73 81.82 81.82 89.09 65.91 63.64 68.18 63.64 65.91 93.18 95.45 94.09 93.18 93.18 67.73 67.73 67.27 67.27 67.96 74.55 75.23 75 75.46 75.68 89.55 90.91 89.09 90 89.55 71.82 72.27 70.91 73.64 70 74.09 74.55 73.64 73.64 75.46 133.18 132.73 132.73 Page 3 multicenter 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 46 49 49 49 49 49 49 49 49 49 49 51 51 51 51 51 51 64 64 64 64 64 64 64 64 3644 3644 3645 3647 3647 3647 3647 3647 3648 3648 3648 3650 3650 3650 3650 3650 3651 3651 3651 3651 3651 3652 3652 3652 3652 3652 4590 4590 4590 3342 3342 3342 3342 3342 3343 3343 3343 3343 3343 3841 3841 3841 3841 3841 3842 4001 4001 4001 4001 4001 4003 4003 4003 4 5 1 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 1 2 3 4 5 1 2 3 9 12 0 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 0 3 6 9 12 0 3 6 1 0.25 1.38 0.5 1.25 1.25 1.25 0.5 2 2.25 4 2 2.25 2.25 2.25 1.5 0.5 0.75 2 1 1.25 1 0 0 0 0 1.75 2.25 0.75 0.75 0.25 0.25 0.5 0 1 1.25 1.75 0 0 2.25 1.75 1 1.25 0.75 2.25 1.25 2 0.5 1 1 1.5 0.75 0.75 1 0 1 0 1 1 1 0 2 2 4 2 3 3 3 2 0 1 4 2 2 0 0 0 0 0 1 1 1 0 0 0 0 0 1 1 3 0 0 3 2 0 1 1 3 1 1 0 0 1 0 0 0 1 0 2 1 2 2 2 1 3 2 4 2 3 3 3 2 0 0 0 0 0 2 0 0 0 0 0 2 0 0 0 0 0 0 0 2 1 0 0 2 1 0 0 0 0 1 2 0 1 1 0 0 0 1 1 1 0 2 2 2 1 0 1 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 3 0 1 0 0 1 0 1 1 2 0 0 1 2 2 2 1 3 1 2 0 1 1 3 1 0 1 0 1.5 1 0 0 0 0 3 4 4 2 3 3 3 2 2 2 4 2 3 2 0 0 0 0 2 3 2 2 1 1 1 0 2 1 1 0 0 3 2 2 2 1 3 2 3 2 2 1 3 2 3 133.64 133.18 89.09 75.91 75.46 75.46 76.36 76.36 80 80.91 80 72.73 72.73 71.82 71.82 72.27 67.27 68.18 68.18 68.18 67.73 94.09 94.09 95.46 98.18 98.18 77.27 78.18 77.5 86.36 86.36 86.82 85 85.91 80 80.46 81.36 80.46 81.82 80.91 78.18 79.09 78.64 78.64 94.55 97.27 96.36 95.46 96.36 95.91 78.18 80 79.77 Page 4 multicenter 64 64 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 4003 4003 3522 3522 3522 3522 3522 3523 3523 3523 3523 3525 3526 3526 3526 3526 3526 3527 3527 3527 3528 3530 3530 3530 3530 3530 3532 3532 3532 3532 3532 3533 3533 3533 3533 3533 3534 3534 3534 3534 3534 3537 3537 3537 3537 3537 3538 3538 3538 3538 3538 3539 3539 4 5 1 2 3 4 5 1 2 3 4 1 1 2 3 4 5 1 2 3 1 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 9 12 0 3 6 9 12 0 3 6 9 0 0 3 6 9 12 0 3 6 0 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0.5 0.5 0.75 1 1 1 0.75 2.25 1 0.75 0.75 2.25 1.5 2 1 4 3 1.25 0.5 0.75 0.5 2.25 0.5 0.5 1 0.5 1.75 3 1.25 1.25 1 2.25 1.25 1.5 0.75 0.75 1.25 1.5 0.75 0.5 0.75 0.5 0.5 0.25 0.25 0.25 1.75 0.5 0 0 0.25 2 0.75 0 0 0 1 1 1 1 2 1 1 1 1 1 2 1 4 3 1 1 2 0 1 0 0 0 0 0 3 1 1 1 2 2 0 0 0 2 1 1 1 1 0 0 0 0 0 2 0 0 0 0 2 0 0 0 0 1 1 1 1 2 1 1 1 3 2 2 1 4 3 1 0 0 0 2 0 0 0 0 2 2 1 1 1 3 0 2 1 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 2 1 0 0 1 1 1 1 0 3 1 0 0 2 1 2 1 4 3 1 0 0 1 3 1 0 2 0 3 3 1 1 1 2 0 1 0 0 0 2 0 0 1 0 0 0 0 0 1 0 0 0 0 2 1 2 2 2 1 1 1 1 2 1 1 1 3 2 2 1 4 3 2 1 1 1 3 1 2 2 2 2 4 2 2 1 2 3 3 2 3 2 2 2 1 1 2 2 1 1 1 3 2 0 0 1 2 1 79.55 80.46 101.59 99.09 99.09 98.41 99.09 71.36 71.36 73.64 75.46 144.55 73.86 76.82 76.82 76.59 75.91 85.46 86.14 85.23 75 88.18 88.64 88.64 90.23 90.46 77.73 81.82 82.27 83.64 83.18 75.46 73.64 73.64 74.77 75 78.41 79.09 79.09 79.77 78.86 85 85.46 85.46 85 85 113.18 112.73 113.64 113.64 114.09 87.5 88.18 Page 5 multicenter 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 68 70 70 70 70 70 70 70 70 70 70 70 3539 3539 3539 4341 4341 4341 4343 4343 4343 4343 4343 4344 4344 4344 4344 4344 4345 4345 4345 4345 4345 4347 4348 4348 4350 4350 4350 4350 4350 4352 4352 4352 4353 4353 4353 4353 4353 4355 4355 4355 4355 4355 3622 3622 3622 3622 3622 3623 3623 3623 3623 3624 3624 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 1 2 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 1 2 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 0 3 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 0 3 1 1 1 1.25 1 0 2 1 0.75 1 1 2 0.25 0.25 1 0 2 1.5 0.75 0.75 0.75 1.75 3.75 2.75 0.75 1.25 1 2.5 1.5 1.25 0.75 0.75 2 0.75 1 1 0.75 1.25 1 1 1 1 2.75 1 0.75 0.5 0.5 1.75 1 1 0 1.75 0.5 1 1 1 0 1 0 1 1 1 1 1 2 0 0 2 0 2 1 1 1 1 2 3 3 0 2 2 2 2 0 1 1 0 0 0 0 0 1 2 2 2 2 3 1 0 0 0 2 1 1 0 1 0 1 1 1 3 1 0 3 2 1 1 1 0 0 0 0 0 0 1 0 0 0 0 4 3 0 0 0 3 0 2 0 0 3 1 1 1 1 1 0 0 0 0 3 1 1 0 0 1 1 1 0 2 0 1 1 1 0 1 0 1 0 0 1 1 3 0 0 0 0 3 1 1 1 1 2 4 3 1 1 0 3 2 1 1 1 2 1 1 2 1 1 2 2 2 2 2 1 1 1 1 2 1 1 0 2 2 1 1 1 2 1 0 3 1 1 1 1 3 1 1 2 0 3 3 1 1 1 3 4 2 2 2 2 2 2 2 1 1 3 1 2 1 1 2 0 0 0 0 3 1 1 1 1 2 1 1 0 2 0 87.73 87.27 87.27 88.18 89.09 88.64 77.73 79.55 78.18 79.09 80 96.82 94.55 95.46 97.96 95 90.46 90 90 90 90.91 69.55 79.55 80 56.36 55.91 56.36 55 54.77 84.09 82.73 82.73 91.59 91.36 89.09 92.05 90 111.14 112.27 109.77 107.96 109.55 72.27 74.55 72.27 72.73 73.18 60.46 60 60 60 65 64.55 Page 6 multicenter 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 75 75 75 75 75 75 75 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 3624 3624 3624 3625 3625 3625 3625 3625 3628 3628 3628 3628 3628 3629 3629 3629 3629 3629 3631 3631 3631 3631 3631 3632 3632 3632 3632 3632 3861 3861 3861 3861 3863 3863 3863 4241 4241 4241 4241 4241 4242 4242 4242 4242 4242 4245 4245 4246 4246 4246 4246 4246 4248 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 4 5 1 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 9 12 0 0.5 0.25 0.25 1.75 1 0.25 0.75 0.5 1.5 2.25 1.25 1 0.5 0.5 0.75 0 0.5 0.25 2 1.75 1.5 1.75 0.75 2.5 2.5 1 0 0 2.5 1 0.5 1 0 0 1 1.25 0.5 0.5 0.5 1.75 0.5 0.25 0 0 2.75 1.75 1.25 0.25 0.25 0.25 0.25 2 0 0 0 1 0 0 0 0 1 1 2 0 0 0 1 0 1 1 1 1 2 2 1 2 2 1 0 0 3 1 0 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 2 0 0 1 0 0 3 2 2 1 0 0 0 0 0 2 2 1 2 1 2 2 1 0 0 3 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 4 3 3 0 0 0 0 2 2 1 1 2 2 1 2 2 3 3 1 2 1 2 2 0 1 0 2 2 2 1 0 3 3 1 0 0 2 2 0 0 0 0 0 2 0 0 0 1 0 0 0 0 3 3 0 0 0 0 0 1 0 0 0 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0 3 2 1 2 1 3 3 1 0 0 2 1 2 2 0 0 3 3 2 2 2 2 2 1 0 0 4 1 1 1 1 1 1 3 81.82 66.36 66.36 126.36 124.55 122.73 125.91 126.82 56.82 57.27 56.82 56.36 58.64 78.18 76.36 71.82 77.27 78.18 69.09 68.64 67.73 68.64 68.64 67.73 69.09 68.18 68.64 68.64 93.64 94.55 95 92.27 88.18 88.64 60.91 60.46 62 62 62 56.36 56.82 55.91 55.91 59 86 85 63.64 64.55 63.64 63.64 63.64 85 Page 7 multicenter 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 89 4248 4248 4248 4248 4249 4249 4249 4249 4249 4250 4250 4250 4250 4250 4252 4252 4253 4255 4255 4255 4255 4255 4256 4256 4256 4256 4256 4258 4259 4259 4259 4481 4481 4481 4481 4481 4482 4482 4482 4482 4482 4484 4484 4484 4484 4484 4485 4485 4485 4485 4485 4487 4487 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 1 1 2 3 4 5 1 2 3 4 5 1 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 3 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0 0 3 6 9 12 0 3 6 9 12 0 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 6 0.25 1.75 1.5 1.5 4 1.5 1.5 1 1.5 3.25 1.5 0.75 0.75 0.25 2 1 1.25 2.75 0 0 0 0 2.25 1.25 1 0.75 0.75 1.5 2.5 0.5 0 2.75 1.75 1.75 1.25 1 2.75 1.5 1.5 2.25 2 2.5 0.75 1 0.5 0.75 2.75 2.25 1.75 2.25 1.25 3.75 0.75 0 1 1 1 4 1 1 0 0 4 1 1 1 0 1 0 0 2 0 0 0 0 0 0 0 0 0 1 3 1 0 3 2 2 1 1 3 2 2 2 2 3 0 0 0 0 3 2 2 3 2 4 2 0 2 2 2 4 1 2 2 2 1 2 0 0 0 2 1 4 3 0 0 0 0 3 2 1 1 1 2 3 0 0 0 1 1 1 1 3 2 2 3 2 3 1 1 1 1 4 3 2 3 2 3 0 0 1 1 1 4 2 2 2 2 4 2 1 1 0 2 1 0 3 0 0 0 0 3 2 2 1 1 1 0 0 0 4 3 3 2 1 3 1 1 2 2 2 1 2 1 2 0 0 0 0 0 4 0 1 3 2 2 4 2 1 0 2 4 1 1 1 1 3 2 1 3 0 0 0 0 3 1 1 1 1 2 4 1 0 4 1 1 1 1 2 1 1 2 2 2 1 1 0 0 4 4 3 3 1 4 1 85 84 84 85 49.8 50 50 49.5 50.8 70 70 68.18 68.64 68.9 75 75 64 96 96 95 94.8 95 100 100 98.3 98.5 99 68 91 90.8 87 50.8 51 50.8 51 51 49 48.5 50 50 50.5 68 69 69 69.5 69.3 71 71 72 72.7 73 79 79 Page 8 multicenter 89 89 89 89 89 89 89 91 91 91 91 91 91 91 91 91 91 91 91 91 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 4487 4487 4489 4489 4489 4489 4490 3681 3681 3681 3681 3681 3683 3683 3683 3685 3685 3685 3685 3685 4221 4221 4221 4223 4223 4224 4224 4225 4225 4225 4225 4225 4227 4227 4227 4227 4227 4229 4229 4229 4229 4229 4230 4230 4230 4230 4230 4231 4231 4231 4231 4231 4234 4 5 1 2 3 4 1 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 1 2 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 9 12 0 3 6 9 0 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 0 3 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 0.25 0.25 3.75 1.5 1 1.75 3 3 0.5 0.25 0.25 0.75 0 0 0 1.25 1 1.25 1 1 2.75 2 1.5 2 1.75 1.5 1 0.5 0 0.75 1.25 0.75 0.75 0.5 0.75 2.25 1.75 1.75 1.75 1.75 2 0.25 0 0.5 0.25 1.25 1.5 0.75 1 2 1.25 0 0 4 3 2 2 2 3 0 0 0 0 0 0 0 0 0 2 0 0 3 2 2 2 1 2 1 1 0 1 2 1 1 1 1 2 2 2 2 2 3 1 0 1 1 2 2 1 1 2 2 0 0 4 1 0 0 3 3 0 0 0 0 0 0 0 1 4 3 4 4 2 2 0 2 2 2 1 0 0 0 3 1 0 0 1 3 2 2 2 2 3 0 0 0 0 2 0 0 1 2 0 0 0 3 0 0 3 3 3 0 0 0 0 0 0 0 1 0 0 0 0 3 2 2 2 2 0 1 0 0 1 0 0 1 1 0 2 1 1 1 1 0 0 0 0 0 0 2 0 1 2 1 1 1 4 2 2 2 4 3 2 1 1 3 0 0 0 3 0 0 0 0 3 2 2 2 2 2 1 1 0 1 0 1 1 0 1 2 2 2 2 2 2 0 0 1 0 1 2 2 1 2 2 79.1 77 62 62 62 62 66 85 86.82 85.91 87.73 121.36 118.64 89.09 88.18 89.32 88.18 59.09 63.64 75 53.64 55.46 81 82 81 80 83 67.27 68 67.73 69 67.73 55.91 56.36 56.36 56.36 55.91 67.73 65.91 63.64 63.64 61.82 81.82 80 79.55 81.82 80 50 Page 9 multicenter 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 208 208 208 208 208 208 208 209 209 209 209 209 209 209 209 209 209 209 4234 4235 4235 4235 4236 4236 4236 4237 4237 4237 4237 4237 4240 4240 4240 4240 4240 4461 4461 4462 4462 4462 4463 4465 4465 4465 4466 4466 4466 4466 4468 4468 4468 4468 4468 4062 4062 4065 4065 4065 4065 4065 3022 3022 3023 3023 3023 3023 3023 3024 3024 3024 3024 2 1 2 3 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 1 1 2 3 1 2 3 5 1 2 3 4 5 1 2 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 3 0 3 6 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 0 0 3 6 0 3 6 12 0 3 6 9 12 0 3 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 1.75 1.75 1.5 2 1 2.25 1.25 0.5 0.25 0 0 1.25 0.5 0.5 0.5 0 0.5 1 0.75 0.75 0.75 1.25 1.75 1 0.75 0.75 1.5 1 1 1 1 0 0 0 2.25 2 2 0.75 0.5 0.5 0.5 1 2.75 1.5 0 0.5 0.5 0.5 2.25 0.75 0 0 3 3 2 3 0 3 1 0 0 0 0 1 0 0 0 0 0 0 1 1 1 0 3 1 0 0 1 0 1 2 2 0 0 0 2 1 2 1 1 1 1 0 1 0 0 0 0 0 1 0 0 0 2 2 2 1 0 3 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 3 1 1 1 2 2 2 1 1 1 0 0 0 3 3 0 0 0 0 0 0 3 1 0 0 0 0 2 0 0 0 0 0 0 2 2 3 2 0 1 0 0 2 1 1 1 0 0 0 1 1 1 0 0 1 1 0 1 0 1 0 0 0 0 0 2 2 3 1 1 1 1 4 4 3 0 2 2 2 3 0 0 0 2 2 2 2 2 0 2 2 0 0 0 2 1 1 1 0 2 4 0 0 0 2 3 1 1 1 2 2 1 1 1 0 0 0 2 2 3 1 0 0 0 0 3 2 0 0 0 0 3 3 0 0 88.64 88.64 89 65.91 66.36 63.64 88.18 87.73 88.18 87.73 88.64 75 71.36 71.82 71.82 74.5 81.36 62.27 60 59.55 73.64 84.55 84.55 83.18 71 71 70.91 70.45 80 81.82 78.64 77.73 76.82 80.91 81.36 96.82 97.27 98.18 97.73 97.95 75.91 76.82 96.82 96.36 95.91 95.45 94.32 84.09 85 84.09 Page 10 multicenter 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 209 227 227 227 227 227 227 227 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 3024 3025 3025 3025 3025 3025 3028 3028 3028 3028 3028 3029 3029 3029 3029 3029 3030 3030 3030 3032 3032 3032 3032 3032 3722 3722 3722 3723 3723 3723 3723 3901 3901 3901 3901 3901 3903 3903 3903 3903 3903 3904 3904 3904 3904 3904 3905 3905 3907 3907 3907 3907 3907 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 1 2 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 4 5 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 0 3 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 9 12 0.5 1.75 1.5 1 1 1.75 2.25 0.5 0.25 1.5 0.25 0.75 0.5 1 0 0 2 0.25 0.75 0.5 0.5 0.75 0.25 1.5 0 1 0.25 0.25 0 1.25 1.25 0.5 0.5 0.5 1.25 0.75 0.25 0 0 2.25 2 1 1 1.5 2.5 2 1.25 0.5 0.5 0.5 0.5 0 0 1 0 0 0 1 0 0 2 0 0 0 0 0 0 3 0 0 1 1 1 0 1 0 2 0 0 0 2 3 0 0 0 1 0 0 0 0 2 2 2 1 2 2 1 1 1 1 1 1 1 2 1 1 1 2 3 0 0 0 0 0 0 2 0 0 0 0 2 0 0 0 0 2 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 2 2 0 1 1 3 3 1 0 0 0 0 0 2 2 1 1 2 2 0 0 1 0 2 0 0 0 0 3 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 2 1 0 1 1 3 2 1 0 0 0 0 1 3 2 2 2 3 3 2 1 3 1 1 2 2 0 0 2 0 1 1 1 2 1 2 0 2 1 1 0 2 2 2 2 2 1 2 1 0 0 3 3 2 1 2 2 2 2 1 1 1 1 82.95 80 80.68 81.05 81.95 82.73 91.27 93.18 91.82 91.36 90.45 74.32 74.55 76.36 75.45 73.18 78.41 78.86 75.23 77.27 77.05 77.73 77.27 82 82 77.27 78.5 81 81.82 82.27 81.36 82.27 94.09 95.45 96.82 97.95 96.36 89.09 89.55 93.18 93.86 57.73 57.27 90 90.68 90.68 90.23 90.23 Page 11 multicenter 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 233 236 236 236 236 236 245 245 245 245 245 3909 3909 3909 3909 3909 3911 3911 3911 3911 3911 3913 3913 3913 3913 3913 3914 3914 3914 3914 3914 3915 3915 3915 3915 3915 3916 3916 3916 3916 3916 3918 3918 3918 3919 3919 3919 3919 3919 4421 4421 4421 4421 4421 3181 3181 3181 3181 3181 3201 3201 3201 3203 3203 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 1.75 2.5 1 1 1 0.75 1.25 0.5 0.25 0.25 4 1 0.5 0.5 1 1.75 0.5 0.5 0.25 0.25 1.5 1.5 1.75 1.25 1 1.75 2 0.75 0.75 1 1 1.25 2.75 3.25 0.75 0 0.25 1.25 0.75 0.5 0.5 0.5 1.25 0.75 1 0.5 0.5 1 2.5 2.25 1.25 1.75 2 3 2 2 1 0 0 0 0 0 4 1 0 0 0 1 0 0 0 0 0 1 2 2 1 2 2 1 1 1 0 0 0 4 1 0 0 3 1 0 0 0 1 1 1 0 0 0 2 3 1 2 0 2 0 0 0 2 2 0 0 0 4 1 0 0 0 2 0 0 0 0 2 2 2 1 1 2 2 0 0 1 2 3 4 2 0 0 0 1 0 0 0 0 3 2 2 2 2 2 4 3 1 1 2 2 0 0 0 0 0 0 0 0 4 0 0 0 2 1 0 0 0 0 2 2 2 1 1 0 2 0 0 0 2 2 4 3 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 0 1 2 3 3 2 2 3 1 3 2 1 1 4 2 2 2 2 3 2 2 1 1 2 1 1 1 1 3 2 2 2 2 0 0 3 4 2 0 1 1 1 1 1 1 1 0 1 0 0 2 4 3 2 2 78.41 76.36 76.82 76.36 77.27 66.82 66.82 68.64 68.18 60.32 60.45 60.45 60.45 85.45 85 85.23 86.36 85.91 81.82 84.09 84.55 84.55 84.55 83.86 81.36 81.36 81.82 81.82 80.91 80 74.55 73.86 75 73.86 74.09 98.64 99.09 99.09 100 100 93.64 92.05 90.68 91.82 90 75.91 76.36 76.82 66.82 67.27 Page 12 multicenter 245 245 245 262 262 262 262 262 262 262 262 262 262 262 262 262 262 262 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 300 3203 3203 3203 4281 4281 4281 4281 4281 4282 4282 4282 4282 4282 4285 4285 4285 4285 4285 3001 3001 3001 3001 3001 3003 3003 3004 3004 3004 3004 3004 3005 3005 3005 3005 3005 3007 3007 3009 3010 3010 3010 3011 3011 3011 3011 3011 3013 3013 3013 3013 3013 3015 3015 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 5 1 2 1 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 12 0 3 0 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 1.75 1.25 2 0.5 0.25 0.75 0.25 0.75 0.25 0.5 0.25 0.25 1 2 1 0.5 0 1 0.5 0.25 0.25 0.25 2 0.75 1.75 1.25 1 1 1.5 1.5 1.25 0.75 0.75 0.25 0.75 2 1 1 0.75 1.75 1.5 2 0.25 0 2 1.5 2.5 1.5 0.5 1.5 1.75 2 1 2 2 0 0 0 0 0 0 0 0 0 2 1 1 0 3 0 0 0 0 3 3 2 1 2 1 2 3 1 1 0 0 1 2 0 1 0 1 1 1 1 0 1 1 3 0 0 2 2 1 1 2 0 0 1 0 0 0 0 0 0 1 2 0 0 0 0 1 0 0 0 2 0 2 1 0 0 2 0 0 1 1 0 0 2 0 1 1 2 0 2 0 0 2 1 2 2 0 2 1 2 1 2 0 0 0 0 0 0 0 0 0 0 2 2 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 4 1 1 1 0 1 1 0 0 2 2 2 0 0 2 2 2 2 1 1 2 2 2 2 0 1 2 1 3 1 2 1 1 3 2 1 0 0 1 1 1 1 1 3 0 3 2 2 3 2 3 0 0 1 0 2 3 3 2 2 2 3 3 0 0 3 2 3 2 1 1 2 67.27 66.36 66.82 80 81.82 79.55 83.18 79.55 98.18 54.09 99.09 100.91 100.91 116.36 115.46 114.09 118.18 120.46 88.64 89.23 88.64 89.32 90.05 78.18 79.55 115.91 111.36 110.91 113.18 112.73 77.27 77.27 74.09 75.46 75 93.18 70.91 87.27 87.27 85.68 106.36 109.55 105 105.46 105.46 95.46 93.64 92.73 70 70.91 Page 13 multicenter 300 300 300 300 300 300 300 300 300 301 301 301 301 301 301 301 301 301 301 301 301 301 301 301 301 301 301 302 302 302 302 302 303 303 303 304 304 304 304 304 304 304 304 304 304 304 304 304 304 304 304 306 306 3015 3015 3016 3016 3016 3016 3018 3018 3018 3041 3041 3041 3041 3041 3042 3042 3042 3044 3044 3044 3044 3044 3045 3045 3045 3045 3045 3123 3123 3123 3123 3123 3101 3101 3101 3142 3142 3142 3142 3142 3143 3143 3144 3144 3144 3144 3144 3146 3146 3146 3146 3981 3981 3 4 1 2 3 4 1 2 3 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 1 2 6 9 0 3 6 9 0 3 6 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 0 3 2 1.5 0.5 0.25 0.75 1.25 1.5 2 2 1.5 0.75 0 1.25 0 1.75 3.5 1.75 1.75 2 2.75 2 2.25 2.5 0.5 0.5 0.5 0.5 3 2 1 0.75 1 3 1.25 1.75 2 1 1.5 1.25 1.5 0.5 0.5 2 0.5 0.25 0.25 0 2.5 2 2 3 3 1.5 2 0 0 1 3 3 1 1 2 1 0 0 1 0 0 2 2 0 2 2 2 1 2 0 0 0 0 3 2 0 0 1 3 1 1 0 0 0 1 0 1 0 2 0 0 0 0 1 2 2 3 3 2 2 2 1 0 0 0 2 2 2 1 1 0 1 0 2 4 1 2 2 3 2 3 2 0 0 0 0 3 1 1 1 1 3 2 2 3 1 2 0 2 0 0 2 0 0 0 0 3 2 2 3 3 2 2 2 1 0 0 2 0 2 2 2 1 0 1 0 2 4 1 1 2 3 2 1 3 0 0 0 0 3 2 1 1 1 3 2 2 2 1 2 0 2 0 0 2 0 0 0 0 3 2 2 3 3 0 2 2 0 0 0 0 3 3 2 2 1 0 2 0 3 4 3 4 2 3 2 4 3 2 2 2 2 3 3 2 1 1 3 0 2 3 2 2 4 2 1 2 2 2 1 1 0 3 2 2 3 3 2 69.09 69.55 73.18 72.27 73.64 72.73 99.55 100 100 88.18 90.46 92.73 90.91 89.09 84.09 88.18 85.91 102.27 103.64 102.27 103.86 103.64 104.55 103.32 100.46 99.32 99.09 75.91 76.36 75 75.46 75.91 91.36 90 88.18 86.82 85.91 87.27 84.77 83.41 90 86.36 93.64 96.36 95.91 97.73 95.91 70.23 72.27 71.82 73.64 74.55 74.32 Page 14 multicenter 306 306 306 306 306 306 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 307 308 308 308 308 309 309 309 310 310 310 310 310 310 310 310 311 311 311 311 311 311 311 316 316 316 316 316 3981 3981 3981 3983 3983 3983 3062 3062 3062 3062 3062 3063 3063 3063 3063 3063 3064 3064 3064 3064 3064 3066 3066 3066 3066 3066 4041 4041 4041 4042 4081 4081 4081 4301 4301 4301 4301 4301 4303 4303 4303 4022 4022 4023 4023 4023 4023 4023 3222 3222 3223 3223 3224 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 1 2 3 1 2 3 4 5 1 2 3 1 2 1 2 3 4 5 1 2 1 2 1 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 0 3 6 0 3 6 9 12 0 3 6 0 3 0 3 6 9 12 0 3 0 3 0 1.25 1.75 1.5 2 1 0.5 1.25 0.5 0.25 0.25 0.25 3 1.75 1.5 1.5 2.25 2.25 0.75 1.25 0.5 0.75 1 0.25 0.25 1.25 0 1.25 0.5 0 1.75 2.75 1.25 0.75 1 0 0.5 0 0 2.5 1.5 0 2 1.5 1.25 0.25 0.25 0.25 0.25 1.75 0.5 1.75 0.63 0.75 2 2 2 2 1 0 3 1 0 0 0 2 1 0 0 2 3 1 0 0 0 1 0 0 0 0 0 0 0 1 3 1 1 0 0 1 0 0 2 1 0 3 2 1 0 0 0 0 0 0 3 0 0 1 2 1 2 1 1 0 0 0 0 0 2 2 2 2 2 2 0 1 0 1 1 1 0 1 0 1 0 0 3 3 1 0 3 0 0 0 0 2 2 0 2 1 1 1 1 1 1 2 1 0 0 2 0 1 1 2 0 0 0 0 0 0 0 4 2 2 2 3 1 0 2 2 2 0 0 0 0 0 2 2 0 2 3 1 0 0 0 0 0 0 2 2 0 1 1 0 0 0 0 0 1 0 3 1 1 2 2 2 2 2 1 2 1 1 1 1 4 2 2 2 2 3 2 2 0 0 2 0 1 4 0 2 0 0 1 2 2 2 1 0 1 0 0 4 1 0 2 2 3 0 0 0 0 4 1 1 1.5 0 74.18 75.68 74 72.73 73.86 74.55 73.64 74.09 73.64 73.18 72.73 87.27 86.82 86.36 87.27 88.18 89.55 89.09 88.64 87.27 90 92.27 91.36 91.36 90.91 90.91 60 56.36 55 59.55 112.27 115.91 115 81.82 80 79.55 81.82 81.82 69.55 72.27 71.82 110.46 109.09 90.91 90.91 90.91 91.82 91.36 104.55 103.86 65 64.55 95 Page 15 multicenter 316 316 316 316 316 316 316 316 316 316 316 316 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 319 319 319 319 319 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 3224 3224 3224 3224 3226 3226 3227 3229 3229 3229 3229 3229 3242 3242 3242 3243 3243 3243 3243 3243 3244 3244 3244 3245 3245 3245 3245 3245 3301 3301 3301 3301 3301 3421 3421 3421 3421 3421 3422 3422 3422 3424 3424 3424 3424 3424 3425 3425 3430 3430 3430 3430 3430 2 3 4 5 1 2 1 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 1 2 3 4 5 3 6 9 12 0 3 0 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 0 3 6 9 12 0.5 0.25 0.25 0 2.75 1.75 2 1.25 0.75 0.75 0.75 0.75 2.5 1 0.75 1.25 0.5 0.5 0.5 0.75 3 2.25 1.25 1.5 0.25 0 0 0 2.75 1.5 2 1.5 1.75 0.75 0 0.25 0 0 0.75 0.5 0.5 1 0.5 1.75 1 1 2 1.5 0.25 1 1.5 2.25 1.5 0 0 0 0 3 0 1 3 1 1 1 1 2 1 1 0 0 0 0 0 3 2 1 0 0 0 0 0 3 1 1 2 3 0 0 0 0 0 0 0 0 0 0 1 2 0 1 2 0 1 0 2 2 0 0 0 0 3 2 3 2 1 1 1 1 3 1 1 1 0 0 0 0 3 1 1 2 1 0 0 0 3 2 2 2 2 1 0 0 0 0 0 0 0 1 0 2 1 0 2 2 0 0 2 2 0 1 0 0 0 3 2 2 0 0 0 0 0 3 0 0 3 1 2 2 3 3 3 1 1 0 0 0 0 2 1 3 1 1 0 0 0 0 0 1 0 0 0 0 2 0 1 2 0 0 1 2 3 2 1 1 1 0 2 3 2 0 1 1 1 1 2 2 1 1 1 0 0 0 3 3 2 3 0 0 0 0 3 2 2 1 1 2 0 1 0 0 2 2 2 3 2 2 1 3 3 2 1 2 2 2 2 94.09 95.46 91.36 95 66.36 65.91 85 114.09 114.09 115 115.46 115.46 85 85.46 84.55 60.46 59.55 59.32 60.46 60.23 76.36 74.55 73.64 99.09 101.36 99.32 100.46 100 78.18 78.18 81.36 81.36 79.55 74.09 75 73.18 74.55 73.64 81.36 81.36 81.82 107.73 105.91 107.73 108.18 107.73 62.27 62.27 100.46 99.55 99.09 99.55 99.09 Page 16 multicenter 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 321 325 325 325 325 325 325 325 325 325 325 325 326 326 326 326 326 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 3432 3432 3432 3432 3432 3433 3433 3433 3433 3433 3434 3434 3434 3436 3436 3436 3436 3436 3438 3661 3661 3661 3662 3662 3662 3662 3665 3665 3665 3665 3701 3701 3701 3701 3701 4161 4161 4163 4163 4163 4163 4163 4164 4164 4164 4164 4164 4166 4166 4166 4166 4166 4167 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 2 1 2 3 1 2 3 4 1 2 3 4 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 3 0 3 6 0 3 6 9 0 3 6 9 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 0.75 1 0.75 1.25 0.5 2.25 1.5 2 1.75 1.25 1 1.75 1.5 1.75 0.5 1.25 0.75 0.75 1.75 2 1.5 2 0.75 1 0.25 0.25 1.5 0.5 1.25 1.38 4 2.5 1.5 2.25 2 2.75 1 1.75 0.75 1 0.25 0.5 0.5 1 1 0.75 0.5 1.25 1 0.5 0.75 0.25 1.25 0 0 0 0 1 2 1 2 2 1 1 2 2 2 0 2 0 0 2 2 2 2 1 1 0 0 1 1 1 1.5 4 2 2 2 2 3 2 3 1 2 0 1 1 3 2 1 0 0 1 0 1 0 1 0 2 0 0 0 3 2 2 1 1 1 2 1 2 0 0 0 0 1 2 1 2 0 1 0 0 2 0 1 1.5 4 2 0 2 2 3 0 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1 1 2 1 1 0 1 1 0 0 0 0 0 1 2 1 2 0 0 0 0 0 0 1 0 4 2 0 2 2 2 0 2 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 3 2 3 3 1 3 2 2 3 2 2 2 2 3 2 3 3 3 3 2 2 2 2 2 1 1 3 1 2 2.5 4 4 4 3 2 3 2 1 1 1 0 0 1 1 2 2 2 3 3 2 2 1 4 84.55 87.27 85.46 85.46 81.82 85 83.64 85.46 84.55 93.64 97.73 95.46 90.91 90.91 92.73 91.82 90.91 95.46 90.46 92.27 90.91 85.91 85.91 86.36 103.5 103 105 102.73 83.18 80 83.64 81.36 80.46 62.5 79 79 78 80 80 84 86 86 87 85 68.64 70 70 73 71.82 79.09 Page 17 multicenter 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 4167 4167 4167 4167 4168 4168 4168 4168 4168 4171 4171 4171 4171 4171 4172 4172 4174 4174 4174 4174 4174 4175 4175 4175 4175 4175 4176 4176 4176 4176 4176 4178 4178 4178 4179 4179 4179 4179 4179 4321 4321 4321 4322 4322 4322 4323 4323 4325 4325 4325 4325 4325 4326 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 1 2 3 1 2 1 2 3 4 5 1 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 0 3 6 0 3 0 3 6 9 12 0 0.5 0.25 0.25 0 0.75 3 3 2 1 0.75 0 0 0 0 2 2.75 1.75 0.25 0.25 0 0 1 0.75 0.75 0.75 0.25 2.75 0.25 0.25 0 0.25 0.25 0.25 0 3.25 2.25 1.75 3 3 2 1.25 0.5 1.75 1.25 0 1.5 1.25 3 1.25 0.75 1.75 0.25 1.25 1 0 0 0 1 3 3 0 1 3 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 2 1 3 3 0 0 0 4 2 0 3 1 1 0 0 0 0 1 0 0 0 0 0 4 3 3 1 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 4 2 0 3 3 0 0 0 0 2 0 0 2 4 2 1 2 0 0 0 0 0 0 0 1 2 2 1 0 0 0 0 0 3 4 3 0 1 0 0 4 3 3 3 1 4 0 0 0 1 0 0 0 4 3 4 3 3 4 3 0 3 1 0 3 2 4 1 1 2 0 2 1 1 1 0 2 4 4 3 1 0 0 0 0 0 4 3 4 1 0 0 0 0 0 0 0 0 2 1 1 0 0 1 1 0 3 2 2 3 3 4 2 2 0 0 0 0 0 3 2 1 3 1 2 79.09 78.18 79 79.55 83.64 85 83.64 84 84.55 89.09 89.09 89.09 91 90.91 87.27 81.36 79.55 80 80.45 80.45 80.91 41.36 41.36 39 41.36 40.45 70.91 70.45 70.45 70 70 79.5 74.5 75 78.64 79.09 79.09 80 79.09 62.27 63 62 62 62.23 61.82 50.45 49.09 79.55 79.55 79.55 79 79.09 84 Page 18 multicenter 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 330 331 331 331 331 331 331 331 331 331 331 331 4326 4326 4326 4326 4328 4328 4330 4331 4331 4331 4332 4334 4334 4334 4336 4336 4337 4337 4337 4338 4340 4340 4340 4340 4509 4509 4509 4509 4511 4511 4513 4513 4514 4514 4514 4514 4516 4516 4516 4517 4517 4517 4181 4181 4181 4181 4181 4182 4182 4182 4182 4182 4184 2 3 4 5 1 2 1 1 2 3 1 1 2 3 1 2 1 2 3 1 1 2 3 4 1 2 3 4 1 2 1 2 1 2 3 4 1 2 3 1 2 3 1 2 3 4 5 1 2 3 4 5 1 3 6 9 12 0 3 0 0 3 6 0 0 3 6 0 3 0 3 6 0 0 3 6 9 0 3 6 9 0 3 0 3 0 3 6 9 0 3 6 0 3 6 0 3 6 9 12 0 3 6 9 12 0 1 0.75 0.5 0.5 3 1.5 1 2.25 2 0 2.75 2 0 0.25 2.5 2.5 1 0.75 0 1.5 2.25 2.25 2 1.75 1.75 1 0.5 0.5 1.25 1.25 1.5 2.25 0.25 0 0 0 1 0 0 2 0.75 0.5 1.75 1.5 2 2.5 1.75 1.75 1.75 1.5 1.25 2 0.75 3 0 0 0 0 0 0 1 4 0 2 0 0 0 1 1 1 0 0 0 1 2 2 2 2 2 2 2 0 0 1 1 0 0 0 0 2 0 0 0 0 0 2 2 2 2 1 0 2 2 0 1 1 0 0 0 0 4 2 0 0 0 0 3 0 0 0 2 2 0 1 0 3 2 2 2 2 0 0 0 0 1 2 0 2 0 0 0 0 0 0 0 2 1 0 2 1 2 2 2 3 2 2 3 3 0 0 0 0 2 4 2 2 4 2 0 3 4 0 1 3 3 3 2 0 3 3 2 2 1 2 0 0 0 1 1 3 3 1 0 0 0 0 0 0 3 1 1 2 2 2 3 2 0 0 0 0 0 2 1 3 2 0 4 2 2 4 2 0 3 4 0 0 4 4 0 0 0 0 3 3 2 2 3 2 0 0 3 2 2 3 0 0 0 0 2 0 0 3 1 1 1 1 2 3 2 4 3 2 2 4 0 84 84.09 84.09 84.09 52.73 54 86.82 69.09 68.18 68.18 78.64 51 50.91 50.91 50 47.73 81.36 83.18 82.73 65.91 60.45 59 59 59 66.36 68.18 68.18 68.18 71.82 72.27 90 90 70.45 70.45 70.45 64.55 64.55 65.46 65 65 65 82.2 81.5 81 80 79.2 54.2 54.5 54.3 55 52.4 109.5 Page 19 multicenter 331 331 331 331 331 331 331 331 331 331 331 331 331 331 331 331 331 331 332 332 332 332 332 332 332 332 332 335 335 335 335 335 335 335 335 335 335 336 336 336 336 336 336 336 336 336 336 336 336 336 336 336 336 4184 4184 4184 4184 4186 4186 4186 4186 4187 4187 4187 4187 4187 4188 4188 4188 4188 4188 4201 4201 4203 4203 4204 4204 4204 4204 4204 3442 3442 3442 3442 3442 3443 3443 3443 3443 3443 3501 3501 3501 3501 3501 3502 3502 3502 3502 3502 3504 3504 3504 3504 3504 3505 2 3 4 5 1 2 3 4 1 2 3 4 5 1 2 3 4 5 1 2 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 3 6 9 12 0 3 6 9 0 3 6 9 12 0 3 6 9 12 0 3 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 1.5 1.5 1.25 0.25 1.25 0.5 0.5 0.5 1.75 0.75 0.25 0 0 2.25 2 2 2 1.5 3 2.25 2.5 2.25 0.75 1 0.75 0.5 0.5 1.5 2 2 2 2 1.75 1 1.75 0.5 0.75 3 2 2 2 2 0.75 1 0.75 0.5 1 3 3 2 1.25 3 3 1 1 0 0 0 0 0 0 1 0 0 0 0 3 3 3 2 2 4 2 4 3 0 2 2 2 1 1 1 2 2 2 3 0 4 0 0 3 2 2 2 2 1 1 0 0 1 3 3 2 1 3 3 2 2 1 0 0 0 0 0 0 1 0 0 0 1 1 0 1 0 3 4 2 2 0 0 0 0 0 2 3 2 2 2 0 0 0 0 0 3 2 2 2 2 0 1 0 1 1 3 3 2 1 3 3 2 2 2 0 2 0 0 0 3 0 0 0 0 3 3 2 3 2 2 1 2 2 1 0 0 0 0 1 3 2 2 2 1 0 0 0 2 3 2 2 2 2 1 2 2 1 2 3 3 2 1 3 3 1 1 2 1 3 2 2 2 3 2 1 0 0 2 1 3 2 2 3 2 2 2 2 2 1 0 1 2 1 2 2 2 3 4 3 2 1 3 2 2 2 2 1 0 1 0 0 3 3 2 2 3 3 112 110 112 110.7 49 48.5 49.1 74.7 75 73.8 74 74 60.8 61.5 60.9 61.5 60.8 64 64 86.36 102.27 99.09 98.9 98.64 90.55 79.55 79.55 81.36 82.73 61.36 61.82 62.73 60 62.73 73.64 76.36 75.9 76.2 76.7 74.55 75.91 74.8 76.8 76.2 89.5 89.4 89.6 89.9 88.1 78.18 Page 20 multicenter 336 336 336 336 336 337 337 337 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 3505 3505 3505 3505 3507 3541 3541 3541 3561 3561 3561 3561 3561 3562 3562 3564 3564 3564 3564 3564 3565 3565 3565 3565 3565 3567 3567 3567 3567 3567 3568 3568 3568 3568 3570 3570 3570 3570 3570 3572 3572 3572 3572 3572 3573 3573 3574 3574 3576 3576 3576 3576 3576 2 3 4 5 1 1 2 3 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 1 2 3 4 5 1 2 3 4 5 1 2 1 2 1 2 3 4 5 3 6 9 12 0 0 3 6 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 0 3 6 9 12 0 3 6 9 12 0 3 0 3 0 3 6 9 12 2.25 2 3 3 2 3.5 2 2.75 1.75 0.5 0.5 0.75 0.5 3 1.25 2.25 0 2 1.25 0 1.75 0 1 0.75 0.75 2.5 0.5 0.75 0.75 0.25 2 0.75 0.5 0.75 2.75 2 1 0.75 0.5 3.75 1 0.75 0.5 0.75 2 2 1.75 2.25 3 0.75 1 1 0.5 2 2 3 3 2 4 4 4 1 1 0 1 1 0 1 0 0 2 1 0 0 0 1 1 1 2 1 1 1 0 2 1 1 1 1 2 1 1 1 3 1 2 0 1 0 1 1 1.5 3 1 1 1 0 2 2 3 3 2 4 0 3 2 0 0 0 0 4 1 3 0 2 1 0 3 0 1 0 0 4 0 0 0 0 0 0 0 0 4 2 1 1 0 4 1 0 0 0 3 3 3 2 3 0 1 0 0 3 2 3 3 3 2 0 0 2 0 0 0 0 4 1 3 0 2 1 0 2 0 0 0 0 1 0 1 1 0 3 1 0 1 2 2 1 0 0 4 1 0 0 0 3 2 1 2.5 3 1 1 1 1 2 2 3 3 1 4 4 4 2 1 2 2 1 4 2 3 0 2 2 0 2 0 2 2 2 3 1 1 1 1 3 1 1 1 4 2 1 1 1 4 1 1 2 2 2 2 2 3 3 1 1 2 1 76 77 77.5 78 88 37.96 38.18 38.18 81.82 82.73 81.82 82.27 82.73 83.64 84.55 113.64 108.64 110 109.09 110.46 119.09 120.46 120.46 118.64 119.55 79.09 75.46 75 75.46 73.64 73.18 72.73 73.18 73.18 57.73 59.09 60.91 58.18 56.36 80.46 79.09 79.55 80.46 79.55 66.82 67.5 81.82 82.96 63.18 62.73 62.73 62.73 62.27 Page 21 multicenter 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 338 339 339 339 339 339 339 339 339 339 339 339 339 339 344 344 344 344 344 344 344 3578 4441 4441 4441 4441 4441 4443 4443 4443 4443 4443 4445 4445 4445 4445 4445 4446 4446 4447 4447 4447 4447 4447 4449 4449 4449 4449 4449 4451 4451 4451 4452 4452 3482 3482 3482 3483 3483 3483 3483 3483 3484 3484 3484 3484 3484 3781 3781 3781 3781 3781 3783 3783 1 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 1 2 3 4 5 1 2 3 4 5 1 2 3 1 2 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 0 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 0 3 6 9 12 0 3 6 9 12 0 3 6 0 3 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 1.5 1.5 0.5 0.5 1.25 0.5 3 1.75 0.75 0.5 0.5 1.25 0.75 0.75 0.75 0.75 2 1 1.75 0.75 0 0 0.25 2.75 0.75 1.5 1.75 1 2 1 1.25 2.75 1 1.5 0.25 0.25 3.75 2.25 1 0.5 2 1.75 1.75 0.5 1.25 1.75 2 2.75 1.75 2 2.25 0.25 0.5 1.5 0 0 0 0 0 4 2 1 0 1 2 0 0 0 0 1 0 3 1 0 0 0 3 1 1 2 2 0 1 1 3 2 2 0 0 3 1 1 0 1 1 0 0 0 2 1 2 1 2 3 0 0 2.5 0 0 0 0 0 2 2 1 0 0 0 0 0 0 0 4 2 2 0 0 0 0 2 0 0 0 0 3 1 1 3 0 2 0 0 4 3 0 0 2 4 3 1 3 3 1 3 2 2 2 0 0 0 3 0 0 2 0 3 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 3 0 2 2 0 2 1 1 2 0 0 0 0 4 4 1 2 4 1 2 0 0 0 3 3 2 2 2 0 0 2 3 2 2 3 2 3 2 1 2 1 3 3 3 3 3 3 2 2 1 0 0 1 3 2 3 3 2 3 1 2 3 2 2 1 1 4 1 2 0 1 1 2 1 2 2 3 3 2 2 2 1 2 86.36 62.27 62.27 61.36 63.18 61.36 102.27 104.55 99.55 100.91 95.46 108.86 109.09 108.64 108.64 109.77 108.18 109.55 65 64.55 65.23 65.46 65 72.73 72.73 72.73 71.82 71.82 82.73 87.27 86.82 97.73 98.18 75 74.55 76.36 82.73 81.82 82.73 82.73 82.73 81.82 81.82 81.82 81.82 81.82 115.91 115.46 115.68 116.36 115.91 82.73 82.27 Page 22 multicenter 344 344 344 344 344 344 344 344 344 344 344 344 344 345 345 345 345 345 345 345 345 345 345 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 346 3783 3783 3783 3784 3784 3784 3784 3784 3786 3786 3786 3786 3786 3801 3801 3801 3801 3801 3802 3802 3802 3802 3802 3821 3821 3821 3821 3821 3823 3823 3823 3823 3823 3824 3824 3824 3824 3824 3825 3825 3825 3825 3825 3827 3827 3827 3827 3827 3829 3829 3829 3829 3829 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 1 1 1 1.75 2 2 1.25 1.25 3.25 1.5 1.75 0.25 0.25 2 0.5 0.5 0.25 0.25 2 1 1 0.5 0.75 0.75 0.5 0.75 0.5 0.5 1.5 1.25 0.75 1.5 1 2 1.5 1.5 1.5 1.5 2 2.75 2 1.5 1.5 1 2 2.75 3 2.5 1 2.5 1.75 1.5 1.75 2 2 2 1 2 2 1 1 4 2 1 0 0 0 1 0 0 0 2 1 0 0 0 0 0 1 0 1 1 2 1 1 0 1 1 1 1 1 1 2 2 1 1 1 1 3 3 2 0 2 1 1 1 0 0 0 3 2 2 1 1 4 1 2 0 0 0 0 0 0 0 2 1 0 0 0 1 0 1 1 0 1 0 0 2 2 2 2 3 2 1 2 3 2 2 1 0 2 3 3 2 2 3 2 1 2 0 0 0 3 2 2 2 2 1 1 2 0 0 4 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 2 2 2 2 2 1 1 1 2 3 3 3 1 2 1 2 2 3 2 0 2 2 2 2 2 2 2 0 2 2 1 1 4 2 2 1 1 4 1 2 1 1 2 2 4 2 3 2 2 1 1 1 3 1 0 1 0 3 2 1 2 2 2 3 1 2 2 2 3 3 3 4 2 3 2 2 2 82.27 84.09 84.55 52.73 53.18 53.41 52.73 53.64 62.96 62.73 63.41 63.18 64.32 95.46 98.18 95.46 99.09 97.73 81.36 80.91 80 81.82 82.73 78.18 78.18 78.64 79.09 80 64.09 64.55 63.18 64.55 64.09 72.73 73.18 73.64 74.09 73.18 81.82 82.27 83.64 82.73 84.55 78.18 78.64 78.64 79.09 79.55 52.27 52.73 52.27 51.82 51.82 Page 23 multicenter 347 347 348 348 348 348 348 348 348 348 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 349 3881 3881 3921 3921 3921 3921 3921 3923 3923 3923 3942 3942 3942 3942 3942 3943 3943 3943 3943 3943 3944 3944 3944 3944 3944 3946 3946 3946 3946 3946 1 2 1 2 3 4 5 1 2 3 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 0 3 0 3 6 9 12 0 3 6 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0 3 6 9 12 0.75 0.25 1.25 1 0.75 1 1 0.5 0.25 0 1 1.25 0.75 0 0.25 2 0.5 0.75 0.75 0.25 2 0.5 0.25 0.5 0.5 1.75 1 1 1.25 1.5 3 0 3 2 1 1 2 1 0 0 2 1 1 0 0 3 0 2 2 0 3 0 0 0 0 2 2 2 1 2 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 3 0 0 0 0 2 0 0 0 0 3 1 1 1 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 2 2 2 3 2 1 1 0 2 2 1 0 1 2 1 1 1 1 3 2 1 2 2 2 1 1 2 2 63.96 59 77.27 78.64 77.27 78.18 75.46 69.09 69.55 67.27 116.82 116.82 112.73 110.68 111.36 89.09 87.73 87.73 87.96 86.82 84.09 82.73 81.14 81.82 81.59 85.91 85.91 91.14 100.68 102.96 Page 24 multicenter si_sysbp si_diabp si_hr 118 82 140 70 140 80 120 70 120 80 100 70 110 72 110 80 drug 68 80 80 82 80 72 70 80 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 1 1 4 4 4 4 4 1 1 1 1 1 4 1 1 1 1 1 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 4 118 122 120 124 134 130 130 150 132 140 160 140 156 100 132 130 144 168 180 112 130 120 120 130 140 125 130 126 130 122 124 128 132 160 132 120 138 180 184 144 80 80 80 82 90 90 84 80 70 86 84 90 82 70 80 80 84 92 90 76 62 80 80 70 70 70 70 70 74 68 64 64 60 80 70 80 70 110 100 92 68 80 84 84 84 80 80 100 86 78 80 70 74 80 80 70 84 80 92 76 60 78 78 84 72 72 60 66 68 72 72 60 60 78 68 56 80 74 44 Page 25 multicenter 160 162 140 130 132 140 160 140 150 129 130 120 116 120 120 210 155 144 160 146 160 150 140 134 124 130 146 130 126 126 152 130 120 130 110 120 112 136 126 140 142 142 156 150 148 130 124 120 130 70 84 80 80 74 80 100 90 90 79 80 70 80 85 80 100 100 88 90 84 100 90 80 84 80 80 100 70 72 80 98 80 60 70 60 80 68 82 80 84 88 86 90 80 82 82 76 80 70 60 56 80 80 88 80 60 88 90 80 66 92 88 88 88 72 72 60 68 80 72 72 92 88 56 72 76 76 72 60 64 72 60 80 78 80 80 80 82 64 70 80 72 64 72 72 80 86 4 4 1 1 1 1 1 1 1 1 4 1 1 1 1 1 4 4 4 4 4 4 4 1 1 1 1 1 1 4 4 4 4 4 4 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 1 Page 26 multicenter 120 130 120 170 130 120 120 130 120 120 124 120 120 130 110 114 116 110 124 120 130 138 118 124 118 88 102 90 90 94 124 110 122 122 114 110 132 110 118 110 120 110 120 124 102 110 118 100 104 80 110 110 112 80 70 70 100 70 70 60 70 60 70 80 60 70 90 70 78 74 90 76 86 88 88 84 82 88 58 68 62 62 60 80 70 80 76 86 80 86 80 70 70 60 60 80 82 68 60 60 66 60 60 80 80 80 72 68 82 82 84 72 72 82 82 86 82 84 68 66 84 72 88 78 88 60 80 80 64 80 64 64 68 56 64 60 72 72 72 68 72 72 72 80 80 72 66 92 84 80 80 56 60 72 60 72 80 72 80 1 1 1 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 Page 27 multicenter 120 90 115 160 150 120 140 132 136 150 130 128 150 154 144 130 132 132 128 146 142 156 140 140 150 150 96 104 121 156 140 158 148 152 140 140 142 146 136 124 122 130 126 108 124 126 122 116 118 112 126 130 130 80 64 75 80 88 80 66 80 80 80 80 80 80 90 90 70 88 84 80 82 88 92 82 80 80 84 64 64 79 94 96 94 90 94 70 76 76 86 70 84 80 80 78 70 80 80 80 80 70 70 80 84 88 72 80 79 68 64 72 72 84 80 80 80 80 92 84 80 80 80 68 84 84 84 60 60 80 84 76 80 100 86 86 76 80 64 72 94 88 88 80 62 60 60 56 64 60 66 80 88 80 88 74 80 76 78 1 1 4 1 1 1 1 1 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 4 4 4 4 4 1 1 1 Page 28 multicenter 122 120 150 150 132 160 140 118 128 132 134 132 112 140 130 128 130 144 152 128 130 104 108 112 112 112 124 136 142 140 140 140 124 128 142 128 132 114 128 130 134 120 140 128 132 132 138 144 132 160 124 140 138 80 84 98 100 96 120 110 76 70 84 80 90 80 90 80 88 90 84 90 88 78 78 84 70 74 68 80 80 88 90 100 90 80 80 84 84 88 84 90 82 92 80 90 90 80 90 86 84 86 92 86 90 94 72 84 86 80 80 80 100 80 84 82 88 82 80 80 76 96 84 60 76 76 80 62 82 82 72 78 76 92 82 100 110 80 78 78 82 78 90 102 80 80 86 80 74 64 64 76 70 80 72 82 80 72 62 1 1 4 4 4 4 4 1 1 1 1 4 1 1 1 1 1 4 4 4 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 Page 29 multicenter 128 128 138 128 118 112 138 128 150 150 134 134 132 130 138 138 112 114 120 118 122 106 110 120 114 122 122 124 118 128 140 128 104 120 112 122 110 140 154 140 130 142 120 110 105 130 160 104 110 110 110 110 120 84 84 88 80 70 66 86 80 85 88 94 98 88 90 86 90 74 78 80 80 80 74 80 82 78 78 84 78 78 90 90 78 76 64 64 68 78 90 90 98 90 80 90 80 70 95 90 60 70 80 80 70 80 76 76 64 80 70 102 76 76 80 78 78 112 88 88 86 76 80 66 72 84 78 78 80 78 68 72 72 86 74 80 82 82 38 52 48 48 48 64 92 80 72 64 76 76 75 80 75 76 76 75 60 75 80 4 4 4 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 4 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 1 1 Page 30 multicenter 125 120 120 150 150 150 140 140 120 120 120 110 120 110 110 120 110 120 120 114 110 110 100 160 160 170 150 160 130 120 140 110 126 130 100 110 110 120 110 120 122 130 136 110 130 130 132 130 152 140 120 160 90 80 80 95 90 90 95 85 70 80 80 80 80 70 70 75 70 80 80 80 70 80 80 90 90 100 95 100 80 80 76 70 80 80 60 64 65 70 70 80 78 80 80 80 90 82 60 60 70 78 70 90 80 70 75 80 80 80 75 75 78 72 68 75 75 72 75 80 70 75 75 80 75 80 60 78 80 75 75 76 68 64 72 66 64 60 64 64 72 72 88 75 74 76 78 68 76 74 60 60 93 80 80 84 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 1 1 1 1 1 4 Page 31 multicenter 158 110 120 130 110 118 110 120 120 130 130 110 110 132 150 148 100 100 98 120 110 110 160 154 148 150 140 118 120 130 140 122 120 110 110 110 110 112 110 114 122 118 120 120 120 120 112 110 130 126 120 112 120 84 80 82 80 70 70 70 80 70 80 82 80 78 90 90 90 70 80 78 90 80 80 70 70 80 80 80 70 80 80 90 80 80 60 64 80 70 72 70 70 78 80 80 70 80 55 70 70 84 82 80 70 80 84 80 80 76 72 74 56 64 72 72 74 72 72 72 84 82 72 70 72 72 70 84 80 76 72 80 82 70 84 84 72 80 82 72 70 80 80 78 74 72 76 76 82 76 80 87 80 74 80 80 86 70 72 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 4 1 1 1 1 1 4 4 4 4 4 1 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 Page 32 multicenter 122 110 100 100 132 126 130 120 136 120 130 120 144 146 150 140 146 138 148 128 140 120 120 120 120 115 120 110 100 120 125 140 115 148 143 135 110 110 100 120 130 120 110 105 110 180 126 120 148 130 110 80 80 60 60 90 80 80 70 82 80 80 84 92 90 100 80 100 94 88 80 80 80 80 80 80 85 85 80 75 85 90 80 85 90 90 75 65 65 60 82 80 80 85 85 80 80 85 80 94 80 80 78 68 80 76 76 80 80 64 72 84 76 72 78 88 72 80 100 82 76 76 76 84 84 80 80 72 72 72 72 92 72 84 72 80 76 72 80 60 60 60 72 75 84 80 80 84 60 75 48 84 76 1 1 4 4 4 4 1 4 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 Page 33 multicenter 1 4 4 4 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 4 4 4 1 4 4 4 1 1 1 1 4 4 4 4 4 1 1 4 4 4 4 4 1 1 4 4 4 4 4 1 1 1 1 128 110 105 120 100 105 105 110 108 108 108 135 130 115 118 120 160 230 194 190 165 180 140 160 110 90 92 100 140 136 140 135 128 118 140 120 136 140 130 130 130 130 124 130 142 116 116 110 112 85 70 70 80 60 80 80 84 84 80 72 95 70 75 76 80 95 105 90 98 80 90 80 76 70 60 60 55 78 72 70 78 60 88 94 80 80 90 90 84 90 90 70 90 88 80 80 72 80 64 64 72 84 52 84 72 72 72 72 72 80 76 72 72 72 76 76 72 72 84 72 76 72 76 72 72 72 60 76 72 72 72 88 80 84 88 96 88 80 88 72 78 72 80 72 88 80 72 Page 34 multicenter 104 122 104 108 120 138 122 112 120 124 120 122 110 122 120 150 130 120 120 132 136 110 110 109 140 150 140 150 125 130 125 130 110 122 140 120 120 120 128 130 120 120 110 120 130 130 118 110 110 110 80 90 70 80 80 90 80 60 70 80 86 80 78 78 80 90 80 80 90 90 96 70 70 64 80 80 90 90 75 70 80 78 70 80 90 80 80 70 80 80 78 86 80 80 88 84 74 70 72 75 78 100 90 60 64 68 72 72 80 68 64 72 72 72 72 72 88 80 60 56 76 60 74 88 88 78 84 80 68 90 80 72 92 60 72 80 60 70 72 72 72 92 72 70 60 68 64 88 92 60 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 4 4 4 4 4 Page 35 multicenter 110 110 128 130 126 128 120 120 120 120 136 130 130 127 150 124 150 142 136 140 120 128 115 120 118 125 120 120 110 128 140 130 134 110 120 120 130 130 122 130 140 132 150 128 132 138 132 132 145 130 142 111 110 70 80 80 80 80 78 70 80 80 80 80 70 80 80 95 80 86 90 94 80 80 88 70 84 90 70 70 80 70 78 80 80 82 80 70 82 80 80 78 70 80 70 60 50 88 90 84 56 80 85 70 67 70 80 68 80 72 80 56 72 60 68 64 64 60 68 68 72 64 60 64 68 64 80 60 70 74 68 70 88 60 72 72 64 60 76 70 68 80 70 80 82 84 92 84 64 64 64 76 56 68 72 72 50 75 80 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 4 1 1 Page 36 multicenter 112 108 100 158 148 128 142 130 122 120 120 140 132 132 142 126 136 122 180 165 175 145 170 120 110 150 140 120 126 120 105 110 124 120 120 130 136 120 120 126 130 118 120 110 120 130 120 140 120 180 160 86 64 80 90 100 86 80 98 78 78 80 96 98 88 86 82 88 90 100 80 85 85 82 70 65 80 85 80 80 80 80 70 78 78 80 90 74 70 84 80 80 84 80 90 70 90 80 96 70 100 90 85 100 88 80 80 76 88 84 60 64 72 88 68 80 84 80 80 84 80 84 84 96 68 80 68 84 75 68 68 72 72 60 56 68 60 72 84 76 80 84 64 67 68 68 80 76 76 76 72 76 68 1 1 1 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 Page 37 multicenter 110 110 118 120 120 110 120 140 120 124 130 120 130 127 100 110 120 120 120 110 116 108 122 130 124 140 124 160 130 138 150 138 140 132 138 120 120 120 130 110 130 130 110 114 110 120 110 150 128 106 120 148 124 74 70 80 82 80 80 78 80 70 66 80 86 90 87 64 80 60 80 80 70 78 80 80 90 71 84 105 88 82 80 78 74 80 82 80 80 90 80 90 80 100 80 80 86 86 90 90 90 94 80 90 90 80 66 65 70 70 88 80 80 72 78 66 80 72 76 77 68 84 56 84 64 69 76 72 88 104 77 72 81 72 76 84 68 72 80 64 72 80 72 72 72 80 64 60 72 84 62 70 74 84 82 70 72 60 72 4 4 1 1 1 1 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 1 1 1 1 1 4 4 4 4 4 4 Page 38 multicenter 122 106 140 152 156 162 160 162 160 130 132 130 136 140 150 150 150 152 150 150 150 120 118 130 128 126 132 118 115 120 114 112 108 120 120 124 134 112 150 112 150 134 132 138 138 134 142 134 150 140 110 120 110 76 72 80 94 106 90 90 90 90 90 86 84 82 80 80 80 80 80 76 84 80 70 70 74 72 74 84 82 80 90 80 74 76 70 70 70 70 70 90 80 100 96 88 92 86 90 80 82 90 80 80 74 80 88 58 72 53 62 48 80 80 84 78 78 74 74 76 78 76 80 84 78 80 82 80 78 78 80 80 70 70 72 92 64 62 56 74 68 74 70 56 80 72 80 100 92 72 76 68 84 80 72 80 56 60 60 4 4 4 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 4 4 4 1 1 4 4 4 4 4 1 1 4 4 4 Page 39 multicenter 120 120 110 110 120 136 110 130 120 140 140 160 120 125 130 120 110 112 130 142 170 160 130 130 130 120 120 126 120 126 118 110 118 120 140 124 160 130 170 130 118 128 130 108 110 112 118 110 124 150 120 140 128 90 80 78 80 70 68 80 80 80 90 80 80 90 90 78 72 72 60 78 90 90 92 72 88 92 90 80 86 82 88 84 80 82 84 88 70 82 90 84 80 84 80 80 78 76 68 60 70 86 100 80 80 80 80 64 80 80 80 88 80 80 80 60 60 76 96 80 80 76 68 66 72 72 60 72 72 80 72 84 84 84 72 76 68 76 80 88 84 80 72 76 78 72 68 68 80 60 60 76 80 100 92 108 88 108 100 4 4 4 4 1 1 1 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 Page 40 multicenter 160 130 126 130 126 100 130 102 120 130 130 126 108 98 124 120 108 130 122 162 148 136 177 150 118 150 160 140 134 140 130 110 120 120 140 195 142.5 130 135 110 140 130 125 120 120 111 120 145 108 125 125 160 130 86 70 86 90 72 68 72 60 74 80 84 78 80 60 84 74 72 86 80 88 90 82 88 86 74 76 100 96 90 94.5 85 80 90 85 90 80 80 90 60 60 91 90 80 78 70 70 78 80 72 70 92 101 92 80 68 68 72 64 72 80 76 80 76 80 88 96 72 72 68 72 76 64 74 80 96 60 60 65 64 84 72 76 77 80 72 80 80 80 78 75 78 102 84 84 78 72 78 78 82 90 78 80 90 108 66 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 4 1 1 1 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 1 Page 41 multicenter 130 130 128 138 130 112 120 130 130 155 160 155 162 160 150 140 135 138 140 140 145 90 90 90 91 110 122 138 140 139 133 130 128 130 122 125 128 128 130 112 105 100 128 132 122 100 111 128 123 123 125 123 108 92 72 90 92 80 71 72 92 82 90 110 110 113 100 90 90 72 79 80 80 83 72 68 62 60 72 70 88 90 86 82 80 80 80 78 80 84 80 85 72 69 71 72 68 75 60 78 80 75 75 75 70 75 72 72 80 105 78 82 70 78 78 80 90 78 105 98 90 78 78 72 78 80 102 60 60 68 60 60 68 80 102 90 90 78 72 76 72 78 105 78 90 76 80 72 92 68 70 60 60 90 90 78 72 90 68 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 1 1 1 1 1 4 4 4 1 1 1 4 4 4 4 4 4 4 1 Page 42 multicenter 110 110 112 125 130 102 122 122 118 110 118 95 100 102 120 100 169 115 152 120 130 158 159 160 130 128 125 122 149 150 122 127 120 125 122 125 130 125 130 125 125 124 120 100 120 100 130 130 100 120 110 110 79 79 85 90 80 69 85 88 75 72 90 62 68 65 78 62 119 82 102 82 85 82 80 80 88 82 79 75 92 90 76 83 76 78 75 82 85 80 84 80 80 78 80 70 80 70 70 80 70 80 70 72 68 70 80 82 72 68 90 72 68 72 90 60 68 68 68 60 105 70 78 72 95 78 80 78 90 72 68 72 78 90 80 90 72 70 70 92 98 90 80 68 70 84 80 64 80 70 72 72 80 76 86 108 1 1 1 1 4 4 1 4 4 4 1 4 4 4 1 1 4 4 4 1 4 4 4 4 1 1 1 1 1 1 4 4 1 1 1 1 4 4 4 1 1 1 4 4 4 4 4 1 1 1 1 1 1 Page 43 multicenter 120 120 130 120 120 130 108 104 130 100 130 130 110 110 110 100 124 104 110 112 122 118 128 130 128 124 130 130 126 120 124 122 148 132 140 112 136 130 120 128 132 120 132 132 136 112 102 102 118 134 110 80 80 80 70 70 70 70 70 80 70 80 70 74 68 90 70 80 64 70 90 72 88 90 94 86 82 82 90 82 80 72 70 80 74 90 78 90 90 70 90 88 78 88 92 98 84 70 72 74 88 76 88 100 68 80 68 88 64 60 80 72 76 76 76 88 88 88 80 84 80 84 88 80 88 104 94 60 72 80 64 68 72 64 72 76 72 84 78 96 102 96 78 66 72 84 78 84 72 60 72 60 60 84 1 1 1 1 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 Page 44 multicenter 112 122 130 132 122 98 102 110 95 108 118 108 130 110 107 110 106 118 124 132 118 112 112 114 148 116 124 118 100 110 135 116 124 109 100 98 130 120 120 160 158 150 110 170 126 122 120 124 120 114 110 108 130 78 84 80 82 72 60 88 92 60 78 80 72 90 76 73 75 74 90 70 80 80 76 76 80 80 70 60 82 60 80 80 64 84 65 70 56 82 82 80 92 90 98 74 100 78 72 88 84 76 70 70 64 65 84 84 102 90 72 78 89 72 88 76 68 76 76 88 74 72 60 76 68 64 88 100 60 88 92 84 80 84 92 88 72 60 88 64 76 68 60 64 80 80 80 84 72 100 86 84 72 76 76 80 80 88 88 4 4 4 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 1 1 1 1 1 4 4 4 4 4 4 4 1 1 1 1 1 1 1 Page 45 multicenter 138 138 156 130 134 128 130 126 126 100 140 120 110 124 118 118 110 110 165 130 136 140 168 130 112 138 120 138 120 120 128 140 130 102 112 120 134 110 120 120 110 150 141 138 140 138 100 114 126 120 126 120 120 108 94 108 90 94 96 84 68 80 74 92 90 80 96 90 90 90 80 90 84 94 80 90 82 69 76 75 74 80 80 84 86 74 80 70 70 68 60 60 60 70 100 76 80 70 64 70 74 90 74 80 82 80 104 80 76 72 84 80 68 72 82 80 72 88 72 72 96 84 88 100 74 72 80 76 72 114 84 92 64 78 76 72 78 72 60 84 80 80 88 86 84 84 84 90 57 64 66 64 80 88 64 60 64 68 76 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4 4 Page 46 multicenter 116 130 120 130 160 120 110 148 130 140 150 150 156 140 138 122 134 140 134 126 100 150 140 90 100 112 118 118 122 118 118 126 120 140 120 142 132 138 140 132 124 112 110 140 130 142 130 126 96 100 110 112 110 90 90 80 80 90 70 70 86 78 80 80 80 76 94 98 84 88 88 90 88 70 100 94 60 72 60 62 72 80 80 80 90 80 90 84 80 70 84 90 90 80 70 80 78 80 80 80 80 64 70 80 70 70 75 86 76 80 72 64 64 80 60 64 72 64 68 60 76 64 72 84 69 72 72 72 64 74 72 76 72 76 78 76 80 80 80 74 76 84 84 84 84 84 80 68 84 76 80 76 76 80 76 74 76 76 76 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 Page 47 multicenter 124 134 112 102 112 106 108 184 168 158 162 148 134 144 132 134 114 136 122 118 124 130 122 124 102 112 112 142 124 130 94 104 70 70 70 72 70 100 70 96 110 100 88 98 90 86 70 82 82 80 82 84 70 86 78 84 80 90 84 86 74 78 80 80 88 72 88 92 80 84 84 80 84 80 84 108 88 72 76 68 80 84 80 60 70 80 76 80 84 4 4 4 4 4 4 4 1 1 1 4 4 4 4 4 1 1 1 1 1 4 4 4 4 4 1 1 1 1 1 Page 48 ...
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This note was uploaded on 12/15/2011 for the course STA 4321 taught by Professor Staff during the Spring '08 term at University of Florida.

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