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Unformatted text preview: MIT OpenCourseWare http://ocw.mit.edu 5.36 Biochemistry Laboratory Spring 2009 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms . __________________________________________________________________________ ________________________________________________________________________________ 5.36 Lecture Summary #1 February 3, 2009 Reading assignment for Thursday: Weisberg, E. et al. Second Generation Inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukamia. Nature Rev. Cancer 7 , 345-356 (2007). Posted on : Next Laboratory Session: #1 Topics: I. Background chemistry for Modules 4 and 5 (kinases!) A. Review of kinases and phosphatases B. Abelson kinase (Abl) and Bcr-Abl C. Kinase inhibitors as cancer drug targets II. Overview of Modules 4 and 5 I. BACKGROUND CHEMISTRY FOR MODULES 4 AND 5 (KINASES!) A) REVIEW OF KINASES AND PHOSPHATASES A kinase is an enzyme that catalyzes the transfer of a _______________ group from ATP onto a _____________ (target molecule). substrate O substrate OH ATP + N N N N NH 2 O O P O O- O P O P- O O O- O O- OH OH A phosphatase is an enzyme that catalyzes the ______________ of a phosphate group from a target molecule: the reverse reaction. substrate OH substrate O P O- O- O phosphatase Serine/threonine-kinases phosphorylate target proteins on a Ser or Thr residue. Tyrosine-kinases phosphorylate target proteins on a Tyr residue. H 3 N O OH O serine (Ser, S) threonine (______ , T) tyrosine (Tyr, ___ ) __________________________________________________________________________ ________________________________________________________________________________ 5.36 Lecture Summary #1 February 3, 2009 Reading assignment for Thursday: Weisberg, E. et al. Second Generation Inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukamia. Nature Rev. Cancer 7 , 345-356 (2007). Posted on : Next Laboratory Session: #1 Topics: I. Background chemistry for Modules 4 and 5 (kinases!) A. Review of kinases and phosphatases B. Abelson kinase (Abl) and Bcr-Abl C. Kinase inhibitors as cancer drug targets II. Overview of Modules 4 and 5 I. BACKGROUND CHEMISTRY FOR MODULES 4 AND 5 (KINASES!) A) REVIEW OF KINASES AND PHOSPHATASES A kinase is an enzyme that catalyzes the transfer of a _______________ group from ATP onto a _____________ (target molecule). substrate O substrate OH ATP + N N N N NH 2 O O P O O- O P O P- O O O- O O- OH OH A phosphatase is an enzyme that catalyzes the ______________ of a phosphate group from a target molecule: the reverse reaction. substrate OH substrate O P O- O- O phosphatase Serine/threonine-kinases phosphorylate target proteins on a Ser or Thr residue....
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536lecntwtbnk_1 11.45.23 PM - MIT OpenCourseWare...

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