bannon15 - V. Characteristics and function of eucaryotic...

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Lecture 15: DNA Organization, Replication and Repair Reading Assignment: Chapter 38, pgs. 412-434; Harper’s Biochemistry (25 th edition). Objective: To understand the structures and proteins involved in DNA replication. I. Cellular DNA exists as chromatin A. Nucleosomes 1. Histones II. General characteristics of DNA replication A. Semi-conservative B. Starts at specific sites C. Bidirectional III. General characteristics of DNA polymerases A. Use DNA as a template B. Replicate DNA with high fidelity C. Catalyze the formation of phosphodiester bridge IV. Characteristics and function of procaryotic DNA polymerases
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Unformatted text preview: V. Characteristics and function of eucaryotic DNA polymerases VI. Characteristics and function of other proteins involved in DNA replication VII. Steps in DNA replication VIII. DNA replication at chromosome ends A. General structure of chromosome ends B. Enzyme involved in replication of chromosome ends IX. Types of DNA mutations A. Single base alterations 1. Transitions 2. Transversions B. Two base alterations 1. Pyrimidine dimers C. Chain breaks D. Cross links X. Types of DNA repair systems A. Direct repair B. Excision repair C. Mismatch repair...
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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bannon15 - V. Characteristics and function of eucaryotic...

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