Ch25Notes2009 11.45.23 PM

Ch25Notes2009 11.45.23 PM - Page 1 of 17 Chapter 25 Notes...

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Page 1 of 17 Chapter 25 Notes Biochemistry 461 Fall 20 10 CHAPTER 25: BIOSYNTHESIS OF NUCLEOTIDES Learning objectives: • Know the structures of the building blocks of nucleic acids • purine and pyrimidine bases. • nucleosides, nucleotides • ribonucleotides and deoxyribonucleotides. • Know key reactions in biosynthesis of the triphosphate forms of the four ribonucleotides(for RNA) and the four deoxyribonucleotides (for DNA). • Know how nucleotides can be intercoverted betweem mono, di, and triphosphate forms • Understand the biosynthesis of dTMP. • Know why nucleotide analogs and inhibitors of thymidylate synthase are used in drug therapy for diseases such as cancer, AIDS, herpes, etc. (Fig. 5.1) A nucleic acid (DNA, RNA) is a polymer consisting of 1) pentose sugars (5 Carbon) 2) phosphate 3) Nitrogenous bases (N-containing ring structures)
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Page 2 of 17 Sugars in Nucelic Acids (Fig. 5.2) Ribose: RNA Deoxyribose: DNA Purine and Pyrimidine bases : (Fig 5.4) Parent Bases Bases in DNA and RNA
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Ch25Notes2009 11.45.23 PM - Page 1 of 17 Chapter 25 Notes...

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