chambers34 - CITRIC ACID CYCLE CITRIC -Anaplerosis Reading:...

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CITRIC ACID CYCLE CITRIC ACID CYCLE -Anaplerosis -Anaplerosis Reading: Harper’s Biochemistry Chapter 18 Lehninger Principles of Biochemistry 3rd Ed. pp. 584-592
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OBJECTIVES OBJECTIVES To understand the citric acid cycle as both a source and “sink” for carbon compounds involved in other metabolic pathways. To understand anaplerosis as a mechanism for regulating the flow of intermediates in the citric acid cycle. To understand how the citric acid cycle is essential for supplying acetyl-CoA to the cytoplasm for use in fatty acid biosynthesis.
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In aerobic organisms, the citric acid cycle is an amphibolic pathway , one that serves in both catabolic and anabolic processes. Besides its role in the oxidative catabolism of carbohydrates, fatty acids, and amino acids, the cycle provides precursors for many biosynthetic pathways, through reactions that served the same purpose in anaerobic ancestors. Ketoglutarate and oxaloacetate can serves as precursors for glutamate and aspartate, respectively, by simple transamination, which themselves can act as precursors for other amino acids and nucleotides. Oxaloacetate can be converted to glucose in gluconeogenesis. Succinyl-CoA is a central intermediate of heme groups.
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Role of the citric acid cycle in anabolism. Intermediates of the citric acid cycle are drawn off as precursors in many biosynthetic pathways. Shown in red are four anaplerotic reactions that replenish depleted cycle intermediates
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Anaplerotic reactions replenish Anaplerotic reactions replenish intermediates in citric acid cycle intermediates in citric acid cycle As intermediates are removed to serve as biosynthetic
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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chambers34 - CITRIC ACID CYCLE CITRIC -Anaplerosis Reading:...

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