chambers36 - Oxidative Phosphorylation Oxidative Reading: q...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Oxidative Phosphorylation Oxidative Phosphorylation Reading: Harper’s Biochemistry pp. 130-148 Lehninger Principles of Biochemistry 3rd Ed. pp. 659-690
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
OBJECTIVES OBJECTIVES To understand oxidative phosphorylation, the mechanism by which living organisms utilize redox energy to synthesize ATP.
Background image of page 2
Oxidative Phosphorylation Oxidative Phosphorylation Electron transfer through the respiratory chain releases about 200 kJ per “mole” of electron pairs. This energy is conserved as a proton-motive force. The formation of a mole of ATP from ADP and Pi requires about 30 kJ. How is a concentration gradient of protons transformed to generate ATP?
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Chemiosmotic Theory Chemiosmotic Theory Proposed by Peter Mitchell The proton-motive force, inherent in the proton gradient, drives the synthesis of ATP as protons flow passively back into the matrix through a protein pore associated with ATP synthase
Background image of page 4
Electron transport and ATP synthesis are Electron transport and ATP synthesis are coupled coupled This can be demonstrated when isolated mitochondria are incubated and O 2 consumption and ATP synthesis measured. Inhibitors of the passage of electrons to O 2 (e.g. cyanide, carbon monoxide, and antimycin A) block ATP synthesis.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Conversely, inhibition of ATP synthesis Conversely, inhibition of ATP synthesis blocks electron transport blocks electron transport without ADP, ATP is not made, but also, oxygen is not consumed the toxic antibiotics oligomycin or venturicidin bind to the ATP
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

Page1 / 16

chambers36 - Oxidative Phosphorylation Oxidative Reading: q...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online