chambers38 - Glycogen metabolism and Glycogen metabolism...

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Unformatted text preview: Glycogen metabolism and Glycogen metabolism and control control Reading: Harpers Biochemistry Chapter 20 OBJECTIVES OBJECTIVES To understand how glycogen is synthesized and degraded in liver and muscle. To understand how hormones like adrenalin and glucagon affect glycogen synthesis and breakdown. Glycogen is the major storage form of carbohydrate in animals and corresponds to starch in plants. Occurs mainly in liver and muscle. Biomedical Importance Biomedical Importance Muscle glycogen acts as a convenient source of hexose units for glycolysis within muscle itself. Only depleted significantly after prolonged vigorous exercise. Liver glycogen is largely concerned with storage and export of hexose units for maintenance of blood glucose, particularly between meals. After 12-18h of fasting, the liver becomes nearly depleted of glycogen. Glycogen storage diseases are a group of inherited disorders characterized by deficient mobilization of glycogen or deposition of abnormal forms of glycogen. Glycogenesis- glycogen synthesis Glycogenesis- glycogen synthesis Occurs mainly in muscle and liver. Glucose is phosphorylated to glucose 6-phosphate as in the first step of glycolysis. Glucose-6-phosphate is converted to glucose-1- phosphate by phosphoglucomutase . In this reaction, the enzyme itself becomes phosphorylated and glucose 1,6- bisphosphate is an intermediate. Glucose 6-phosphate Glucose 1-phosphate The key reaction in glycogen synthesis is the formation of UDP-glucose by the action of UDP-glucose pyrophosphorylase....
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chambers38 - Glycogen metabolism and Glycogen metabolism...

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