Chapter4Part1Notes 11.45.23 PM

Chapter4Part1Notes 11.45.23 PM - Page 1 of 31 Chapter 4...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Page 1 of 31 Chapter 4 Notes : Part 1 Biochemistry 461 Fall 20 10 CHAPTER 4 , Part 1: LECTURE TOPICS: DNA and RNA - MOLECULES OF HEREDITY 1) DNA/RNA structures, nomenclature, shorthand conventions 2) DNA and RNA as genetic material 3) General properties of DNA Double Helix 4) Basic mechanism of DNA replication 5) Important physical-chemical properties of DNA Reminder from Chapter 25 Lectures: Nucleic acids (DNA, RNA): are polymers consisting of pentose sugars, phosphate, and bases
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 2 of 31 RNA and DNA are chains of ribo (or dexyribo-)nucleosides connected by 5' to 3' phosphodiester bonds. They are polynucleotides . ** The chains have polarity , and are always written and read from 5' to 3' (left to right) as in the examples of DNA and RNA trinucleotides . (Fig.5.3)
Background image of page 2
Page 3 of 31 Nucleic Acid Shorthand Notations : Trinucleotide shorthand example (Fig.5.7): pACG (see also Powerpoint version)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 4 of 31 DNA and RNA as genetic material: Proofs ! Transformation with pure DNA (Pneumococcus, 1928, 1944) ! Bacteriophage T2 DNA not Protein (1952)
Background image of page 4
Scenario : attach to cell inject DNA reproduce (new DNA and proteins) kill cells release progeny (new) virus infect more cells new BACTERIOPHAGE VIRUS LIFE CYCLE
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 5 of 31 ! TMV - RNA as genetic information (1955) ! Retroviruses: RNA to DNA (1970's) (Fig.5.23)
Background image of page 6
Page 6 of 31 ! PRIONS - Proteins (not DNA or RNA are transmissible agent s (1970's to present)
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Page 7 of 31 DNA (chromosomes) are long as seen by electron microsocopy of E. coli DNA (Fig.5.8) DNA molecules are doble-helices - deduced from x-ray diffraction patterns of B-DNA in 1938. The data showed that there had to be regularly spaced units at 3.4 Angstroms along the helix. (Fig.5.10)
Background image of page 8
Page 8 of 31 DNA Structure: Watson-Crick Double Helix (1953) ! B-DNA was the form upon which Watson and Crick derived their model. DNA occurs primarily in this form in vivo. The important features of this model of DNA are: ! Two helical polynucleotide chains coil around a common axis. The chains are
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 20

Chapter4Part1Notes 11.45.23 PM - Page 1 of 31 Chapter 4...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online