drake3 - Water pH and dissociation Lecture 3 Medical...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Water, pH and dissociation Lecture 3, Medical Biochemistry Lecture 3 Outline • Homeostasis • The structure and function of water • Dissociation of weak acids and weak bases • pH and the Henderson-Hasselbalch equation • Buffers, biological/physiological examples HOMEOSTASIS • The dynamic that defines the distribution of water and the maintenance of pH and electrolyte concentrations • Water distribution maintained by the kidneys, antidiuretic hormone, hypothalamic thirst response, respiration and perspiration • Clinically, need to be aware of water depletion caused by decreased intake (coma, wandering the desert) or increased loss (diarrhea, renal malfunction, over- exercise), and excess body water due to increased intake (too much I.V.) or decreased excretion (renal failure) Structure of H 2 From Lehninger, 2nd ed., Ch 4 WATER • Comprises approx 70% of human mass (45- 60% intracellular, 25% extracellular/blood plasma) • dipolar: partial negative charge on oxygen, partial positive charge on hydrogens • dipolar nature leads to formation of many low energy hydrogen bonds Water Solubility / Hydrophilic From Lehninger, 2nd ed., Ch 4 Hydrophilic/Hydrophobic F r o m L e h n i n g e r , 2 n d e d . , C h 4 Hydrophobicity From Lehninger, 2nd ed., Ch 4 Hydrophobicity/Micelles From Lehninger, 2nd ed., Ch 4 Summary of water and pH...
View Full Document

{[ snackBarMessage ]}

Page1 / 25

drake3 - Water pH and dissociation Lecture 3 Medical...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online