drake4 - The peptide bond(C is a hybrid of A and B giving...

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Biomolecules: Amino Acids and Peptides Lecture 4, Medical Biochemistry
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Lecture 4 Outline Present and discuss the properties of amino acids Discuss the importance of pKa values and amino acid titration curves NOTE: Ignore the techniques section in your book chapter 4 (p. 33-34)
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At physiological pH’s (7.0-7.4), both the carboxyl and amino groups are charged Only L-amino acids are found in proteins
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Non-protein Amino Acids
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Examples of Clinical Aminoacidurias Metabolic defects : Phenylketonuria (Phe), Tyrosinemias (Phe,Tyr), Maple Syrup Urine Disease (Leu, Val, Ile), Alcaptonuria (Tyr) Absorption/transport defects : cystinuria (Cys), Hartnup disease , Fanconi’s Syndrome These diseases are generally diagnosed from indicators in the urine or plasma. These diseases will be discussed further in the amino acid metabolism lectures
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Post-translational Modifications
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BOND PEPTIDE
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Resonance forms of peptide bonds.
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Unformatted text preview: The peptide bond (C) is a hybrid of A and B, giving it a partial double bond character Planar nature of the peptide bond. The partial double bond characteristic prevents free rotation around the C-N bond; keeping it in the same plane with the attached O and H atoms. These planar bonds can pivot around the shared C α atom Trans conformation; most common and sterically favored Cis conformation; found rarely with Pro, sterically unfavorable The planar nature of the peptide bond restricts the possible conformations that a protein can assume. This can be predicted by the angle (above or below the peptide bond plane) of the two bonds between the α-carbon of the constituent amino acids. These phi ( φ ) and psi ( ψ ) angles can be used to predict and define some higher order protein structures. Peptide Bond Steric Restrictions Levels of Protein Structure...
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