drake42 - Sugar Catabolism and Biosynthesis Medical...

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Sugar Catabolism and Biosynthesis Medical Biochemistry, Lecture 42
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Lecture 42, Outline Examine how glucose metabolism relates to other sugars Fructose metabolism and related diseases Galactose metabolism and related diseases Glucuronate metabolism and functions Understand nucleotide sugar interconversions Marks, Marks and Smith Chapter 29, primary source, Harper’s Ch 22 secondary source. Review Ch. 15 for sugar structural properties
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Figure 29.4, MMS UDP-Glucose Metabolism
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High Energy Phosphates in UDP-Glucose Metabolism
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UDP-Glucose Glycosyltranserase Reaction
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Figure 29.6, MMS Glucuronic Acid Metabolism
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Glucuronidation Reactions: (Primarily in liver, intestine) Bilirubin di-glucuronide
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URONIC ACID PATHWAY Glucuronate derived from breakdown of UDP-glucuronate (which ultimately came from glucose via UDP-glucose) Alternative oxidative pathway for glucose Not in humans
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Figure 29.2, MMS Fructose Metabolism
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Fructose Metabolism - Fructose is found in foods containing sucrose (fruits), high- fructose corn syrups, and honey. - Dietary fructose is converted to Fructose-1-P by fructokinase (primarily in the liver, kidney and intestine). - Normal aldolase B function generates dihydroxyacetone phosphate and glyceraldehyde from Fructose-1-P. The affinity of aldolase B for fructose-1-P is much poorer than that of fructose-1,6-biphosphate, thus fructose-1-P accumulates in fructokinase-expressing tissues. Thus, aldolase B is the rate-limiting enzyme for fructose metabolism (but not glucose).
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drake42 - Sugar Catabolism and Biosynthesis Medical...

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