{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

drake42 - Sugar Catabolism and Biosynthesis Medical...

Info icon This preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Sugar Catabolism and Biosynthesis Medical Biochemistry, Lecture 42
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Lecture 42, Outline Examine how glucose metabolism relates to other sugars Fructose metabolism and related diseases Galactose metabolism and related diseases Glucuronate metabolism and functions Understand nucleotide sugar interconversions Marks, Marks and Smith Chapter 29, primary source, Harper’s Ch 22 secondary source. Review Ch. 15 for sugar structural properties
Image of page 2
Figure 29.4, MMS UDP-Glucose Metabolism
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
High Energy Phosphates in UDP-Glucose Metabolism
Image of page 4
UDP-Glucose Glycosyltranserase Reaction
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Figure 29.6, MMS Glucuronic Acid Metabolism
Image of page 6
Glucuronidation Reactions: (Primarily in liver, intestine) Bilirubin di-glucuronide
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
URONIC ACID PATHWAY Glucuronate derived from breakdown of UDP-glucuronate (which ultimately came from glucose via UDP-glucose) Alternative oxidative pathway for glucose Not in humans
Image of page 8
Figure 29.2, MMS Fructose Metabolism
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Fructose Metabolism - Fructose is found in foods containing sucrose (fruits), high- fructose corn syrups, and honey. - Dietary fructose is converted to Fructose-1-P by fructokinase (primarily in the liver, kidney and intestine). - Normal aldolase B function generates dihydroxyacetone phosphate and glyceraldehyde from Fructose-1-P. The affinity of aldolase B for fructose-1-P is much poorer than that of fructose-1,6-biphosphate, thus fructose-1-P accumulates in fructokinase-expressing tissues. Thus, aldolase B is the rate-limiting enzyme for fructose metabolism (but not glucose).
Image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern