drake44 - COMPLEX CARBOHYDRATES Medical Biochemistry,...

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COMPLEX CARBOHYDRATES Medical Biochemistry, Lecture 44
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Lecture 44, What to Study: - Know the structural components and differences between the glycoconjugate types - Know the general biosynthetic and catabolic strategies and molecules involved - Know the general function of each class of glycoconjugate - Know the general biochemical principles associated with diseases resulting from defects in the catabolic pathways of the glycoconjugates
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Lecture 44, Text Sources Marks, Marks and Smith Chapter 30, primary source, Harper’s Ch 56 supersecondary source. Review Ch. 15,16 for sugar and lipid structural properties
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General Biosynthetic and Catabolic Themes for Glycoconjugates - An initial sugar residue is attached to a core protein or lipid, usually through a serine or asparagine residue. - Sugar residues are added sequentially from nucleotide diphosphate sugar donors by specific glycosyltransferases in the endoplasmic reticulum and golgi. - Glycosidases (sugar specific hydrolases) in the lysosome are responsible for degradation and catabolism - Almost all diseases related to glycoconjugates result from defective lysosomal glycosidase function
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UDP-Glucose Glycosyltranserase Reaction
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Figure 29.12a, MMS Sugar Nucleotide Conversions
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Figure 29-12b, MMS Sugar Nucleotide Conversions (cont.)
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drake44 - COMPLEX CARBOHYDRATES Medical Biochemistry,...

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