liverDiseaseAndAnesthesia

liverDiseaseAndAnesthesia - Anesthesia and Liver Disease...

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Anesthesia and Liver Disease E.A. Steele, MD May 4, 2005
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Liver Anatomy
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Liver Anatomy cont.
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Liver Blood Flow Portal Vein 70% of total flow 50% of oxygen (only has 85% sat) Dependent upon flow thru GI tract Hepatic Artery 30% of total flow 50% of oxygen autoregulated to meet liver demand
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Metabolic functions Carbohydrate metabolism – glycogen storage Fat metabolism – fatty acids Protein metabolism – protein deamination to urea, amino acid conversions, plasma protein production Drug metabolism Other - T4 to T3, vitamin storage
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Protein Metabolism Deamination – converts a.a. into carbohydrates/fats with ammonia as by- product. Ammonia is toxic 2(Ammonia) + CO2 = urea Plasma proteins Albumin, coagulation factors (exc. Factor 8 and vWF), plasma cholinesterases, transport proteins
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Bile Bile ducts become R & L Hepatic Ducts become hepatic duct, joined by the cystic duct to form the common bile duct to the sphincter of oddi along with the pancreatic duct
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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liverDiseaseAndAnesthesia - Anesthesia and Liver Disease...

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