mehta52 - Cholesterol and Bile Acid Metabolism Medical...

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Unformatted text preview: Cholesterol and Bile Acid Metabolism Medical Biochemistry Lecture #52 CHOLESTEROL SYNTHESIS, TRANSPORT, AND EXCRETION Cholesterol is present in tissues and in plasma lipoproteins either as free cholesterol or, combined with a long-chain free fatty acid, as cholesteryl ester. It is synthesized in many tissues from acetyl-oA and is eliminated from the body in the bile as cholesterol or bile salts. Cholesterol is the precursor of all other steroids, such as sex hormones, bile acids, and vitamin D. It occurs in foods of animal origin such as egg yolk, meat, liver, and brain. CHOLESTEROL SYNTHESIS, TRANSPORT, AND EXCRETION (cont) A little more than half the cholesterol of the body arises by synthesis (about 700 mg/d), and the remainder is provided by the average diet. The liver accounts for 10% of total synthesis in...
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This note was uploaded on 12/16/2011 for the course BIOLOGY 101 taught by Professor Mr.wallace during the Fall '11 term at Montgomery College.

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mehta52 - Cholesterol and Bile Acid Metabolism Medical...

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